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http://doi.org/10.25358/openscience-10050Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Wolf, Elias V. | - |
| dc.contributor.author | Halfmann, Moritz C. | - |
| dc.contributor.author | Schoepf, U. Joseph | - |
| dc.contributor.author | Zsarnoczay, Emese | - |
| dc.contributor.author | Fink, Nicola | - |
| dc.contributor.author | Griffith, Joseph P. | - |
| dc.contributor.author | Aquino, Gilberto J. | - |
| dc.contributor.author | Willemink, Martin J. | - |
| dc.contributor.author | O'Doherty, Jim | - |
| dc.contributor.author | Hell, Michaela M. | - |
| dc.contributor.author | Suranyi, Pal | - |
| dc.contributor.author | Kabakus, Ismael M. | - |
| dc.contributor.author | Baruah, Dhiraj | - |
| dc.contributor.author | Varga-Szemes, Akos | - |
| dc.contributor.author | Emrich, Tilman | - |
| dc.date.accessioned | 2024-02-19T10:31:16Z | - |
| dc.date.available | 2024-02-19T10:31:16Z | - |
| dc.date.issued | 2023 | - |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/10068 | - |
| dc.description.abstract | Purpose: To compare coronary artery calcium volume and score (CACS) between photon-counting detector (PCD) and conventional energy integrating detector (EID) computed tomography (CT) in a phantom and prospective patient study. Methods: A commercially available CACS phantom was scanned with a standard CACS protocol (120 kVp, slice thickness/increment 3/1.5 mm, and a quantitative Qr36 kernel), with filtered back projection on the EID-CT, and with monoenergetic reconstruction at 70 keV and quantum iterative reconstruction off on the PCD-CT. The same settings were used to prospectively acquire data in patients (n = 23, 65 ± 12.1 years), who underwent PCD- and EID-CT scans with a median of 5.5 (3.0–12.5) days between the two scans in the period from August 2021 to March 2022. CACS was quantified using a commercially available software solution. A regression formula was obtained from the aforementioned comparison and applied to simulate risk reclassification in a pre-existing cohort of 514 patients who underwent a cardiac EID-CT between January and December 2021. Results: Based on the phantom experiment, CACSPCD–CT showed a more accurate measurement of the reference CAC volumes (overestimation of physical volumes: PCD-CT 66.1 ± 1.6% vs. EID-CT: 77.2 ± 0.5%). CACSEID–CT and CACSPCD–CT were strongly correlated, however, the latter measured significantly lower values in the phantom (CACSPCD–CT: 60.5 (30.2–170.3) vs CACSEID–CT 74.7 (34.6–180.8), p = 0.0015, r = 0.99, mean bias –9.7, Limits of Agreement (LoA) –36.6/17.3) and in patients (non-significant) (CACSPCD–CT: 174.3 (11.1–872.7) vs CACSEID–CT 218.2 (18.5–876.4), p = 0.10, r = 0.94, mean bias –41.1, LoA –315.3/232.5). The systematic lower measurements of Agatston score on PCD-CT system led to reclassification of 5.25% of our simulated patient cohort to a lower classification class. Conclusion: CACSPCD–CT is feasible and correlates strongly with CACSEID–CT, however, leads to lower CACS values. PCD-CT may provide results that are more accurate for CACS than EID-CT. | en_GB |
| dc.language.iso | eng | de |
| dc.rights | CC BY | * |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject.ddc | 610 Medizin | de_DE |
| dc.subject.ddc | 610 Medical sciences | en_GB |
| dc.title | Intra-individual comparison of coronary calcium scoring between photon counting detector- and energy integrating detector-CT : effects on risk reclassification | en_GB |
| dc.type | Zeitschriftenaufsatz | de |
| dc.identifier.doi | http://doi.org/10.25358/openscience-10050 | - |
| jgu.type.contenttype | Scientific article | de |
| jgu.type.dinitype | article | en_GB |
| jgu.type.version | Published version | de |
| jgu.type.resource | Text | de |
| jgu.organisation.department | FB 04 Medizin | de |
| jgu.organisation.number | 2700 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | Frontiers in Cardiovascular Medicine | de |
| jgu.journal.volume | 9 | de |
| jgu.pages.alternative | 1053398 | de |
| jgu.publisher.year | 2023 | - |
| jgu.publisher.name | Frontiers Media | de |
| jgu.publisher.place | Lausanne | de |
| jgu.publisher.issn | 2297-055X | de |
| jgu.organisation.place | Mainz | - |
| jgu.subject.ddccode | 610 | de |
| jgu.publisher.doi | 10.3389/fcvm.2022.1053398 | de |
| jgu.organisation.ror | https://ror.org/023b0x485 | - |
| jgu.subject.dfg | Naturwissenschaften | de |
| Appears in collections: | DFG-491381577-G | |
Files in This Item:
| File | Description | Size | Format | ||
|---|---|---|---|---|---|
 | intraindividual_comparison_of-20240205171106807.pdf | 1.45 MB | Adobe PDF | View/Open |