Gutenberg Open Science: Different activity patterns control various stages of Reelin synthesis in the developing neocortex

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-10004

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DC Field	Value	Language
dc.contributor.author	Engeroff, Kira	-
dc.contributor.author	Warm, Davide	-
dc.contributor.author	Bittner, Stefan	-
dc.contributor.author	Blanquie, Oriane	-
dc.date.accessioned	2024-02-14T09:31:55Z	-
dc.date.available	2024-02-14T09:31:55Z	-
dc.date.issued	2023	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/10022	-
dc.description.abstract	Reelin is a large extracellular matrix protein abundantly expressed in the developing neocortex of mammals. During embryonic and early postnatal stages in mice, Reelin is secreted by a transient neuronal population, the Cajal–Retzius neurons (CRs), and is mostly known to insure the inside-out migration of neurons and the formation of cortical layers. During the first 2 postnatal weeks, CRs disappear from the neocortex and a subpopulation of GABAergic neurons takes over the expression of Reelin, albeit in lesser amounts. Although Reelin expression requires a tight regulation in a time- and cell-type specific manner, the mechanisms regulating the expression and secretion of this protein are poorly understood. In this study, we establish a cell-type specific profile of Reelin expression in the marginal zone of mice neocortex during the first 3 postnatal weeks. We then investigate whether electrical activity plays a role in the regulation of Reelin synthesis and/or secretion by cortical neurons during the early postnatal period. We show that increased electrical activity promotes the transcription of reelin via the brain-derived neurotrophic factor/TrkB pathway, but does not affect its translation or secretion. We further demonstrate that silencing the neuronal network promotes the translation of Reelin without affecting the transcription or secretion. We conclude that different patterns of activity control various stages of Reelin synthesis, whereas its secretion seems to be constitutive. Reelin, neocortex, development, neuronal activity, neurotrophic signaling	en_GB
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Different activity patterns control various stages of Reelin synthesis in the developing neocortex	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-10004	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Cerebral cortex	de
jgu.journal.volume	33	de
jgu.journal.issue	15	de
jgu.pages.start	9376	de
jgu.pages.end	9386	de
jgu.publisher.year	2023	-
jgu.publisher.name	Oxford University Press	de
jgu.publisher.place	Oxford	de
jgu.publisher.issn	1460-2199	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1093/cercor/bhad210	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Naturwissenschaften	de
Appears in collections:	DFG-491381577-G

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