Autoren:	Kao, Yu-San Mamareli, Panagiota Dhillon-LaBrooy, Ayesha Stüve, Philipp Godoy, Gloria Janet Velasquez, Lis Noelia Raker, Verena Katharina Weidenthaler-Barth, Beate Boukhallouk, Fatima Rampoldi, Francesca Berod, Luciana Sparwasser, Tim
Titel:	Targeting ACC1 in T cells ameliorates psoriatic skin inflammation
Online-Publikationsdatum:	29-Aug-2023
Erscheinungsdatum:	2023
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	Psoriasis is a chronic inflammatory skin disease driven by the IL-23/IL-17 axis. It results from excessive activation of effector T cells, including T helper (Th) and cytotoxic T (Tc) cells, and is associated with dysfunctional regulatory T cells (Tregs). Acetyl-CoA carboxylase 1 (ACC1), a rate-limiting enzyme of fatty acid synthesis (FAS), directs cell fate decisions between Th17 and Tregs and thus could be a promising therapeutic target for psoriasis treatment. Here, we demonstrate that targeting ACC1 in T cells by genetic ablation ameliorates skin inflammation in an experimental model of psoriasis by limiting Th17, Tc17, Th1, and Tc1 cells in skin lesions and increasing the frequency of effector Tregs in skin-draining lymph nodes (LNs).
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-9475
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	Journal of molecular medicine Version of Record (VoR)
Verlag:	Springer
Verlagsort:	Berlin u.a.
Erscheinungsdatum:	2023
ISSN:	1432-1440
DOI der Originalveröffentlichung:	10.1007/s00109-023-02349-w
Enthalten in den Sammlungen:	DFG-491381577-H