Gutenberg Open Science: Physical activity specifically evokes release of cell-free DNA from granulocytes thereby affecting liquid biopsy

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8177

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DC Field	Value	Language
dc.contributor.author	Neuberger, Elmo W. I.	-
dc.contributor.author	Sontag, Stephanie	-
dc.contributor.author	Brahmer, Alexandra	-
dc.contributor.author	Philippi, Keito F. A.	-
dc.contributor.author	Radsak, Markus P.	-
dc.contributor.author	Wagner, Wolfgang	-
dc.contributor.author	Simon, Perikles	-
dc.date.accessioned	2022-11-07T11:07:42Z	-
dc.date.available	2022-11-07T11:07:42Z	-
dc.date.issued	2022	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8192	-
dc.description.abstract	Physical activity impacts immune homeostasis and leads to rapid and marked increase in cell-free DNA (cfDNA). However, the origin of cfDNA during exercise remains elusive and it is unknown if physical activity could improve or interfere with methylation based liquid biopsy. We analyzed the methylation levels of four validated CpGs representing cfDNA from granulocytes, lymphocytes, monocytes, and non-hematopoietic cells, in healthy individuals in response to exercise, and in patients with hematological malignancies under resting conditions. The analysis revealed that physical activity almost exclusively triggered DNA release from granulocytes, highlighting the relevance as a pre-analytical variable which could compromise diagnostic accuracy.	en_GB
dc.description.sponsorship	Gefördert durch die Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 491381577	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	570 Biowissenschaften	de_DE
dc.subject.ddc	570 Life sciences	en_GB
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.subject.ddc	796 Sport	de_DE
dc.subject.ddc	796 Athletic and outdoor sports and games	en_GB
dc.title	Physical activity specifically evokes release of cell-free DNA from granulocytes thereby affecting liquid biopsy	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8177	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 02 Sozialwiss., Medien u. Sport	de
jgu.organisation.number	7910	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Clinical epigenetics	de
jgu.journal.volume	14	de
jgu.pages.alternative	29	de
jgu.publisher.year	2022	-
jgu.publisher.name	Springer Nature	de
jgu.publisher.place	London	de
jgu.publisher.issn	1868-7083	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	570	de
jgu.subject.ddccode	610	de
jgu.subject.ddccode	796	de
jgu.publisher.doi	10.1186/s13148-022-01245-3	de
jgu.organisation.ror	https://ror.org/023b0x485	-
jgu.subject.dfg	Geistes- und Sozialwissenschaften	de
Appears in collections:	DFG-491381577-G

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