Autoren:	Krenzlin, Harald Lorenz, Viola Danckwardt, Sven Kempski, Oliver Alessandri, Beat
Titel:	The importance of thrombin in cerebral injury and disease
Online-Publikationsdatum:	6-Okt-2022
Erscheinungsdatum:	2016
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	There is increasing evidence that prothrombin and its active derivative thrombin are expressed locally in the central nervous system. so far, little is known about the physiological and pathophysiological functions exerted by thrombin in the human brain. extra-hepatic prothrombin expression has been identified in neuronal cells and astrocytes via mrna measurement. the actual amount of brain derived prothrombin is expected to be 1% or less compared to that in the liver. the role in brain injury depends upon its concentration, as higher amounts cause neuroinflammation and apoptosis, while lower concentrations might even be cytoprotective. its involvement in numerous diseases like alzheimer’s, multiple sclerosis, cerebral ischemia and haemorrhage is becoming increasingly clear. this review focuses on elucidation of the cerebral thrombin expression, local generation and its role in injury and disease of the central nervous system.
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7888
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	International journal of molecular sciences 17 1
Seitenzahl oder Artikelnummer:	Art. 84
Verlag:	Molecular Diversity Preservation International
Verlagsort:	Basel
Erscheinungsdatum:	2016
ISSN:	1422-0067 1661-6596
URL der Originalveröffentlichung:	http://dx.doi.org/10.3390/ijms17010084
DOI der Originalveröffentlichung:	10.3390/ijms17010084
Enthalten in den Sammlungen:	DFG-OA-Publizieren (2012 - 2017)