Gutenberg Open Science: Forensic application and evaluation of a commercially available pregabalin immunoassay test in serum on an Olympus AU480

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-6912

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DC Field	Value	Language
dc.contributor.author	Hess, Cornelius	-
dc.contributor.author	Zeidler, Sandra	-
dc.contributor.author	Röhrich, Jörg	-
dc.date.accessioned	2022-04-27T10:10:56Z	-
dc.date.available	2022-04-27T10:10:56Z	-
dc.date.issued	2021	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/6923	-
dc.description.abstract	Misuse of pregabalin and its forensic relevance is steadily increasing. The aim of this study was to evaluate the usability of the commercially available ARKTM Pregabalin II Assay (ARK Diagnostics) for serum analysis of forensic samples. Overall, 156 samples were tested by both the immunoassay and a validated liquid chromatographic–tandem mass spectrometric (LC-MS/MS) method. Sensitivity was 100%, and specificity was 98.7% (n = 79 positive cases confirmed by LC-MS/MS in a range of 380–37,000 ng/mL). A good correlation (R2 = 0.73) could also be shown between quantitative immunoassay and LC-MS/MS results. In conclusion, the assay shows excellent reliability for screening of forensic serum samples.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Forensic application and evaluation of a commercially available pregabalin immunoassay test in serum on an Olympus AU480	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-6912	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Drug testing and analysis	de
jgu.journal.volume	13	de
jgu.journal.issue	6	de
jgu.pages.start	1216	de
jgu.pages.end	1218	de
jgu.publisher.year	2021	-
jgu.publisher.name	Wiley	de
jgu.publisher.place	Hoboken, NJ	de
jgu.publisher.issn	1942-7611	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1002/dta.2994	de
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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