Autoren:	Krebs, Franziska K. Trzeciak, Emily R. Zimmer, Sophia Özistanbullu, Deniz Mitzel-Rink, Heidrun Meissner, Markus Grabbe, Stephan Loquai, Carmen Tüttenberg, Andrea
Titel:	Immune signature as predictive marker for response to checkpoint inhibitor immunotherapy and overall survival in melanoma
Online-Publikationsdatum:	12-Mai-2021
Erscheinungsdatum:	2021
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	BACKGROUND Malignant melanoma is an immunogenic skin cancer with an increasing global incidence. Advanced stages of melanoma have poor prognoses. Currently, there are no reliable parameters to predict a patient's response to immune checkpoint inhibitor (ICI) therapy. METHODS This study highlights the relevance of a distinct immune signature in the blood for response to ICI therapy and overall survival (OS). Therefore, the immune cell composition in the peripheral blood of 45 melanoma patients prior to ICI therapy was analyzed by flow cytometry and complete blood count. RESULTS Responders to ICI therapy displayed an abundance of proliferating CD4+ T cells, an increased lymphocyte‐to‐monocyte ratio, a low platelet‐to‐lymphocyte ratio, low levels of CTLA‐4+ Treg, and (arginase 1+) polymorphonuclear myeloid‐derived suppressor cells (PMN‐MDSC). Nevertheless, non‐responders with similar immune cell compositions also benefited from therapy displaying increased long‐term OS. CONCLUSION Our study demonstrated that the observed immune signature in the peripheral blood of melanoma patients prior to treatment could identify responders as well as non‐responders that benefit from ICI immunotherapies.
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-5907
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	Cancer medicine 10 5
Seitenzahl oder Artikelnummer:	1562 1575
Verlag:	Wiley
Verlagsort:	Hoboken, NJ
Erscheinungsdatum:	2021
ISSN:	2045-7634
URL der Originalveröffentlichung:	https://doi.org/10.1002/cam4.3710
DOI der Originalveröffentlichung:	10.1002/cam4.3710
Enthalten in den Sammlungen:	JGU-Publikationen