Autoren:	Lagrange, Jeremy Wagner, Bianca Nagler, Markus ten Cate, Vincent Pallares Robles, Alejandro Koeck, Thomas Rapp, Steffen Prochaska, Jürgen H. Spronk, Henri M. Wenzel, Philip Ruf, Wolfram ten Cate, Hugo Wild, Philipp S. Panova-Noeva, Marina
Titel:	Characterization of thrombin generation curve shape in presence of platelets from acute venous thromboembolism patients
Online-Publikationsdatum:	18-Dez-2020
Erscheinungsdatum:	2020
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	Background. Anticoagulant therapy, the cornerstone treatment in acute venous thromboembolism (VTE), strongly impacts thrombin generation (TG). Until now, the appearance of the TG curve in platelet rich plasma (PRP) from patients with acute VTE has not been investigated. Methods. We analyzed the shape of TG curves measured in PARP of 180 acute VTE patients. Results. Normal shape of TG curves was observed in 110 patients, 50 patients showed no TG and 20 patients showed biphasic TG curve. The linear regression analysis, adjusted for age, sex, VTE clinical phenotypes and therapy showed that the appearance of biphasic curves is significantly associated with female sex, presence of cancer and therapy with Factor Xa inhibitors. Conclusions. This study demonstrated that despite taking anticoagulants, TG in presence of platelets is still present in the majority of acute VTE patients. Appearance of unusual TG curves is strongly related to the intake of anti-Factor Xa inhibitors. The clinical relevance of biphasic TG curve appearance requires further investigation. Keywords: thrombin generation venous thromboembolism platelets factor Xa inhibitor
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-5508
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Weitere Angaben zur Dokumentart:	Scientific article
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	Journal of Clinical Medicine 9 9
Seitenzahl oder Artikelnummer:	2892
Verlag:	MDPI
Verlagsort:	Basel
Erscheinungsdatum:	2020
ISSN:	2077-0383
URL der Originalveröffentlichung:	https://doi.org/10.3390/jcm9092892
DOI der Originalveröffentlichung:	10.3390/jcm9092892
Enthalten in den Sammlungen:	JGU-Publikationen