Autoren:	Brüne, Daniel Andrade, Miguel Mier, Pablo
Titel:	Proteome-wide comparison between the amino acid composition of domains and linkers
Online-Publikationsdatum:	23-Jan-2019
Erscheinungsdatum:	2018
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	Objective Amino acid composition is a sequence feature that has been extensively used to characterize proteomes of many species and protein families. Yet the analysis of amino acid composition of protein domains and the linkers connecting them has received less attention. Here, we perform both a comprehensive full-proteome amino acid composition analysis and a similar analysis focusing on domains and linkers, to uncover domain- or linker-specific differential amino acid usage patterns. Results The amino acid composition in the 38 proteomes studied showcase the greater variability found in archaea and bacteria species compared to eukaryotes. When focusing on domains and linkers, we describe the preferential use of polar residues in linkers and hydrophobic residues in domains. To let any user perform this analysis on a given domain (or set of them), we developed a dedicated R script called RACCOON, which can be easily used and can provide interesting insights into the compositional differences between a domain and its surrounding linkers.
DDC-Sachgruppe:	570 Biowissenschaften 570 Life sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 10 Biologie
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-279
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	BMC Research Notes 11
Seitenzahl oder Artikelnummer:	Art. 117
Verlag:	BioMed Central
Verlagsort:	London
Erscheinungsdatum:	2018
ISSN:	1756-0500
URL der Originalveröffentlichung:	http://dx.doi.org/10.1186/s13104-018-3221-0
DOI der Originalveröffentlichung:	10.1186/s13104-018-3221-0
Anmerkung:	Andrade, Miguel veröffentlicht unter: Andrade-Navarro, Miguel A.
Enthalten in den Sammlungen:	JGU-Publikationen