Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-8796
Authors: | Winkelmeier, Laurens Filosa, Carla Hartig, Renée Scheller, Max Sack, Markus Reinwald, Jonathan R. Becker, Robert Wolf, David Gerchen, Martin Fungisai Sartorius, Alexander Meyer-Lindenberg, Andreas Fahr-Weber, Wolfgang Clemm von Hohenberg, Christian Russo, Eleonora Kelsch, Wolfgang |
Title: | Striatal hub of dynamic and stabilized prediction coding in forebrain networks for olfactory reinforcement learning |
Online publication date: | 10-Feb-2023 |
Year of first publication: | 2022 |
Language: | english |
Abstract: | Identifying the circuits responsible for cognition and understanding their embedded computations is a challenge for neuroscience. We establish here a hierarchical cross-scale approach, from behavioral modeling and fMRI in task-performing mice to cellular recordings, in order to disentangle local network contributions to olfactory reinforcement learning. At mesoscale, fMRI identifies a functional olfactory-striatal network interacting dynamically with higher-order cortices. While primary olfactory cortices respectively contribute only some value components, the downstream olfactory tubercle of the ventral striatum expresses comprehensively reward prediction, its dynamic updating, and prediction error components. In the tubercle, recordings reveal two underlying neuronal populations with non-redundant reward prediction coding schemes. One population collectively produces stabilized predictions as distributed activity across neurons; in the other, neurons encode value individually and dynamically integrate the recent history of uncertain outcomes. These findings validate a cross-scale approach to mechanistic investigations of higher cognitive functions in rodents. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-8796 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Nature Communications 13 |
Pages or article number: | 3305 |
Publisher: | Nature Publishing Group |
Publisher place: | London |
Issue date: | 2022 |
ISSN: | 2041-1723 |
Publisher DOI: | 10.1038/s41467-022-30978-1 |
Appears in collections: | DFG-491381577-G |
Files in This Item:
File | Description | Size | Format | ||
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striatal_hub_of_dynamic_and_s-20230210102732794.pdf | 4.97 MB | Adobe PDF | View/Open |