Gutenberg Open Science: Bridging the gap between postembryonic cell lineages and identified embryonic neuroblasts in the ventral nerve cord of Drosophila melanogaster

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-8054

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DC Field	Value	Language
dc.contributor.author	Birkholz, Oliver	-
dc.contributor.author	Rickert, Christof	-
dc.contributor.author	Nowak, J.	-
dc.contributor.author	Coban, I. C.	-
dc.contributor.author	Technau, Gerhard	-
dc.date.accessioned	2022-10-17T07:32:02Z	-
dc.date.available	2022-10-17T07:32:02Z	-
dc.date.issued	2015	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/8069	-
dc.description.abstract	The clarification of complete cell lineages, which are produced by specific stem cells, is fundamental for understanding mechanisms, controlling the generation of cell diversity and patterning in an emerging tissue. In the developing Central Nervous System (CNS) of Drosophila, neural stem cells (neuroblasts) exhibit two periods of proliferation: During embryogenesis they produce primary lineages, which form the larval CNS. After a phase of mitotic quiescence, a subpopulation of them resumes proliferation in the larva to give rise to secondary lineages that build up the CNS of the adult fly. Within the ventral nerve cord (VNC) detailed descriptions exist for both primary and secondary lineages. However, while primary lineages have been linked to identified neuroblasts, the assignment of secondary lineages has so far been hampered by technical limitations. Therefore, primary and secondary neural lineages coexisted as isolated model systems. Here we provide the missing link between the two systems for all lineages in the thoracic and abdominal neuromeres. Using the Flybow technique, embryonic neuroblasts were identified by their characteristic and unique lineages in the living embryo and their further development was traced into the late larval stage. This comprehensive Analysis provides the first complete view of which embryonic neuroblasts are postembryonically reactivated along the anterior/posterior-axis of the VNC, and reveals the relationship between projection Patterns of primary and secondary sublineages.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/3.0/	*
dc.subject.ddc	570 Biowissenschaften	de_DE
dc.subject.ddc	570 Life sciences	en_GB
dc.title	Bridging the gap between postembryonic cell lineages and identified embryonic neuroblasts in the ventral nerve cord of Drosophila melanogaster	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-8054	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 10 Biologie	de
jgu.organisation.number	7970	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Biology open	de
jgu.journal.volume	4	de
jgu.journal.issue	4	de
jgu.pages.start	420	de
jgu.pages.end	434	de
jgu.publisher.year	2015	-
jgu.publisher.name	Company of Biologists	de
jgu.publisher.place	Cambridge	de
jgu.publisher.uri	http://dx.doi.org/10.1242/bio.201411072	de
jgu.publisher.issn	2046-6390	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	570	de
opus.date.modified	2018-09-05T09:05:42Z	-
opus.subject.dfgcode	04-206	-
opus.organisation.string	FB 10: Biologie: Institut für Genetik	de_DE
opus.identifier.opusid	51117	-
opus.institute.number	1005	-
opus.metadataonly	false	-
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Rickert, Christof	-
opus.affiliated	Technau, Gerhard	-
jgu.publisher.doi	10.1242/bio.201411072	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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