Gutenberg Open Science: High stimulus-related information in barrel cortex inhibitory interneurons

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7822

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DC Field	Value	Language
dc.contributor.author	Reyes-Puerta, Vicente	-
dc.contributor.author	Kim, Suam	-
dc.contributor.author	Sun, Jyh-Jang	-
dc.contributor.author	Imbrosci, Barbara	-
dc.contributor.author	Kilb, Werner	-
dc.contributor.author	Luhmann, Heiko	-
dc.date.accessioned	2022-10-04T10:29:25Z	-
dc.date.available	2022-10-04T10:29:25Z	-
dc.date.issued	2015
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7837	-
dc.description.abstract	The manner in which populations of inhibitory (INH) and excitatory (EXC) neocortical neurons collectively encode stimulus-related information is a fundamental, yet still unresolved question. Here we address this question by simultaneously recording with large-scale multi-electrode arrays (of up to 128 channels) the activity of cell ensembles (of up to 74 neurons) distributed along all layers of 3–4 neighboring cortical columns in the anesthetized adult rat somatosensory barrel cortex in vivo. Using two different whisker stimulus modalities (location and frequency) we show that individual INH neurons – classified as such according to their distinct extracellular spike waveforms – discriminate better between restricted sets of stimuli (≤6 stimulus classes) than EXC neurons in granular and infra-granular layers. We also demonstrate that ensembles of INH cells jointly provide as much information about such stimuli as comparable ensembles containing the ~20% most informative EXC neurons, however presenting less information redundancy – a result which was consistent when applying both theoretical information measurements and linear discriminant analysis classifiers. These results suggest that a consortium of INH neurons dominates the information conveyed to the neocortical network, thereby efficiently processing incoming sensory activity. This conclusion extends our view on the role of the inhibitory system to orchestrate cortical activity.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	High stimulus-related information in barrel cortex inhibitory interneurons	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7822	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	PLoS Computational Biology	de
jgu.journal.volume	11	de
jgu.journal.issue	6	de
jgu.pages.alternative	e1004121	de
jgu.publisher.year	2015	-
jgu.publisher.name	Public Library of Science	de
jgu.publisher.place	San Francisco, Calif.	de
jgu.publisher.uri	http://dx.doi.org/10.1371/journal.pcbi.1004121	de
jgu.publisher.issn	1553-7358	de
jgu.publisher.issn	1553-734X	de
jgu.organisation.place	Mainz	-
jgu.identifier.pmid	26098109
jgu.subject.ddccode	610	de
opus.date.modified	2018-09-05T09:15:40Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 04: Medizin: Institut für Physiologie und Pathophysiologie	de_DE
opus.identifier.opusid	51985
opus.importsource	pubmed
opus.institute.number	0403
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Reyes-Puerta, Vicente
opus.affiliated	Imbrosci, Barbara
opus.affiliated	Luhmann, Heiko
jgu.publisher.doi	10.1371/journal.pcbi.1004121	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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