Gutenberg Open Science: Influence of laccase and tyrosinase on the antioxidant capacity of selected phenolic compounds on human cell lines

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7801

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DC Field	Value	Language
dc.contributor.author	Riebel, Matthias	-
dc.contributor.author	Sabel, Andrea	-
dc.contributor.author	Claus, Harald	-
dc.contributor.author	Fronk, Petra	-
dc.contributor.author	Xia, Ning	-
dc.contributor.author	Li, Huige	-
dc.contributor.author	König, Helmut	-
dc.contributor.author	Decker, Heinz	-
dc.date.accessioned	2022-10-04T09:06:48Z	-
dc.date.available	2022-10-04T09:06:48Z	-
dc.date.issued	2015
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7816	-
dc.description.abstract	Polyphenolic compounds affect the color, odor and taste of numerous food products of plant origin. In addition to the visual and gustatory properties, they serve as radical scavengers and have antioxidant effects. Polyphenols, especially resveratrol in red wine, have gained increasing scientific and public interest due to their presumptive beneficial impact on human health. Enzymatic oxidation of phenolic compounds takes place under the influence of polyphenol oxidases (PPO), including tyrosinase and laccase. Several studies have demonstrated the radical scavenger effect of plants, food products and individual polyphenols in vitro, but, apart from resveratrol, such impact has not been proved in physiological test systems. Furthermore, only a few data exist on the antioxidant capacities of the enzymatic oxidation products of phenolic compounds generated by PPO. We report here first results about the antioxidant effects of phenolic substances, before and after oxidation by fungal model tyrosinase and laccase. In general, the common chemical 2,2-diphenyl-1-picrylhydrazyl assay and the biological tests using two different types of cell cultures (monocytes and endothelial cells) delivered similar results. The phenols tested showed significant differences with respect to their antioxidant activity in all test systems. Their antioxidant capacities after enzymatic conversion decreased or increased depending on the individual PPO used.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	530 Physik	de_DE
dc.subject.ddc	530 Physics	en_GB
dc.title	Influence of laccase and tyrosinase on the antioxidant capacity of selected phenolic compounds on human cell lines	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7801	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.department	FB 10 Biologie	de
jgu.organisation.number	2700	-
jgu.organisation.number	7970	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Molecules	de
jgu.journal.volume	20	de
jgu.journal.issue	9	de
jgu.pages.start	17194	de
jgu.pages.end	17207	de
jgu.publisher.year	2015	-
jgu.publisher.name	MDPI	de
jgu.publisher.place	Basel	de
jgu.publisher.uri	http://dx.doi.org/10.3390/molecules200917194	de
jgu.publisher.issn	1420-3049	de
jgu.organisation.place	Mainz	-
jgu.identifier.pmid	26393557
jgu.subject.ddccode	530	de
opus.date.modified	2018-08-22T07:49:46Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 04: Medizin: Institut für Pharmakologie	de_DE
opus.organisation.string	FB 10: Biologie: Institut für Mikrobiologie und Weinforschung	de_DE
opus.organisation.string	FB 10: Biologie: Institut für Molekulare Biophysik	de_DE
opus.identifier.opusid	52281
opus.importsource	pubmed
opus.institute.number	0413
opus.institute.number	1008
opus.institute.number	1009
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Riebel, Matthias
opus.affiliated	Sabel, Andrea
opus.affiliated	Claus, Harald
opus.affiliated	Fronk, Petra
opus.affiliated	Xia, Ning
opus.affiliated	Li, Huige
opus.affiliated	König, Helmut
opus.affiliated	Decker, Heinz
jgu.publisher.doi	10.3390/molecules200917194	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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