Autoren:	Moergel, Maximilian Kämmerer, Peer Kasaj, Adrian Armouti, Evangelia Alshihri, Abdulmonem Weyer, Veronika Al-Nawas, Bilal
Titel:	Chronic periodontitis and its possible association with oral squamous cell carcinoma : a retrospective case control study
Online-Publikationsdatum:	15-Sep-2022
Erscheinungsdatum:	2013
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	INTRODUCTION: Different inflammatory processes may trigger the development of malignancies. Therefore, the aim of the present study was to evaluate a potential association between radiological determined chronic periodontitis (CPA) and oral squamous cell carcinoma (OSCC). METHODS: In a retrospective study, OSCC-patients and a control group without malignant tumors were radiographically examined for bone loss. Via telephone survey and questionnaire, general clinical data on the individual oral hygiene and concomitant diseases together with tobacco and alcohol use were assessed and data were compared between the groups. RESULTS: 178 OSCC-patients and 123 controls were included. In univariate analysis, a statistically relevant higher mean bone loss was seen in the OSCC group (4.3 mm (SD: 1.8; 95% confidence interval (CI): 4-4.6) vs. 2.9 mm (SD: 0.7; 95% CI: 2.8-3); p < 0.001)). This was confirmed in a multivariate regression model (OR: 2.4, 95% CI: 1.5-3.8; p < 0.001). A history of periodontal treatment was associated with significantly reduced OSCC risk (p < 0.001; OR: 0.2, CI: 0.1-0.5). CONCLUSIONS: CPA is a common disease and the monitoring as well as the treatment of such a chronic oral inflammation may be beneficial in reducing one potential cause of OSCC. Therefore, further clinical studies on oral neoplasms should consider clinical periodontal parameters as well.
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7771
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/2.0/
Zeitschrift:	Head & face medicine 9
Seitenzahl oder Artikelnummer:	Art. 39
Verlag:	BioMed Central
Verlagsort:	London
Erscheinungsdatum:	2013
ISSN:	1746-160X
URL der Originalveröffentlichung:	http://dx.doi.org/10.1186/1746-160X-9-39
DOI der Originalveröffentlichung:	10.1186/1746-160X-9-39
Enthalten in den Sammlungen:	DFG-OA-Publizieren (2012 - 2017)