Gutenberg Open Science: Physical exercise induces rapid release of small extracellular vesicles into the circulation

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7770

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DC Field	Value	Language
dc.contributor.author	Frühbeis, Carsten	-
dc.contributor.author	Helmig, Susanne	-
dc.contributor.author	Tug, Suzan	-
dc.contributor.author	Simon, Perikles	-
dc.contributor.author	Albers, Eva-Maria	-
dc.date.accessioned	2022-09-15T07:47:02Z	-
dc.date.available	2022-09-15T07:47:02Z	-
dc.date.issued	2015
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7785	-
dc.description.abstract	Cells secrete extracellular vesicles (EVs) by default and in response to diverse stimuli for the purpose of cell communication and tissue homeostasis. EVs are present in all body fluids including peripheral blood, and their appearance correlates with specific physiological and pathological conditions. Here, we show that physical activity is associated with the release of nano-sized EVs into the circulation. Healthy individuals were subjected to an incremental exercise protocol of cycling or running until exhaustion, and EVs were isolated from blood plasma samples taken before, immediately after and 90 min after exercise. Small EVs with the size of 100-130 nm, that carried proteins characteristic of exosomes, were significantly increased immediately after cycling exercise and declined again within 90 min at rest. In response to treadmill running, elevation of small EVs was moderate but appeared more sustained. To delineate EV release kinetics, plasma samples were additionally taken at the end of each increment of the cycling exercise protocol. Release of small EVs into the circulation was initiated in an early phase of exercise, before the individual anaerobic threshold, which is marked by the rise of lactate. Taken together, our study revealed that exercise triggers a rapid release of EVs with the characteristic size of exosomes into the circulation, initiated in the aerobic phase of exercise. We hypothesize that EVs released during physical activity may participate in cell communication during exercise-mediated adaptation processes that involve signalling across tissues and organs.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY-NC	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/	*
dc.subject.ddc	570 Biowissenschaften	de_DE
dc.subject.ddc	570 Life sciences	en_GB
dc.title	Physical exercise induces rapid release of small extracellular vesicles into the circulation	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7770	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 02 Sozialwiss., Medien u. Sport	de
jgu.organisation.department	FB 10 Biologie	de
jgu.organisation.number	7910	-
jgu.organisation.number	7970	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Journal of extracellular vesicles	de
jgu.journal.volume	4	de
jgu.pages.alternative	Art. 28239	de
jgu.publisher.year	2015	-
jgu.publisher.name	Co-Action Publ.	de
jgu.publisher.uri	http://dx.doi.org/10.3402/jev.v4.28239	de
jgu.publisher.issn	2001-3078	de
jgu.notes.public	Albers, Eva-Maria veröffentlicht auch unter Krämer-Albers, Eva-Maria	de
jgu.organisation.place	Mainz	-
jgu.identifier.pmid	26142461
jgu.subject.ddccode	570	de
opus.date.modified	2018-09-05T09:08:50Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 02: Sozialwissenschaften, Medien und Sport: Institut für Sportwissenschaft	de_DE
opus.organisation.string	FB 10: Biologie: Abteilung Molekulare Zellbiologie / Biologie für Mediziner	de_DE
opus.identifier.opusid	51952
opus.importsource	pubmed
opus.institute.number	0208
opus.institute.number	1004
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Frühbeis, Carsten
opus.affiliated	Helmig, Susanne
opus.affiliated	Tug, Suzan
opus.affiliated	Simon, Perikles
opus.affiliated	Albers, Eva-Maria
jgu.publisher.doi	10.3402/jev.v4.28239	de
jgu.organisation.ror	https://ror.org/023b0x485	-
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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