Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-7389Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Jäckels, Nadine | - |
| dc.contributor.author | Bellinghausen, Iris | - |
| dc.contributor.author | Fronk, Petra | - |
| dc.contributor.author | Heydenreich, Bärbel | - |
| dc.contributor.author | Saloga, Joachim | - |
| dc.contributor.author | Decker, Heinz | - |
| dc.date.accessioned | 2022-07-13T09:17:21Z | - |
| dc.date.available | 2022-07-13T09:17:21Z | - |
| dc.date.issued | 2015 | |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/7403 | - |
| dc.description.abstract | BACKGROUND: In a recently performed survey with 4000 randomly selected persons, 68 (7.2 %) of 948 respondents reported intolerance and/or allergy-like symptoms to wine. The aim of this study was to analyze whether a real sensitization to wine proteins could be confirmed by diagnostic and/or immunological settings. FINDINGS: For this purpose, 19 subjects with self-reported intolerance to wine of the invited subjects and 10 controls without a history of intolerance participated in an allergological examination (skin prick test, ImmunoCAP for determination of specific IgE antibodies, CAST for testing basophil activation, ImmunoBlot for testing specificity of IgE-antibodies). For the allergological work-up red and white grapes, selected wines, and the purified lipid transfer protein (LTP), a known grape allergen, were used. 7 subjects showed evidence of IgE sensitization to wine or grape extracts, including one control. One participant with symptoms of intolerance showed a positive skin prick test to red grape, a positive ImmunoCAP to grape, a positive cellular antigen stimulation test (CAST) and inhibition of Western blot by removal of cross-reactive carbohydrate determinants (CCD). CONCLUSION: The presented study focused on the grape protein-related IgE-mediated cause of intolerance to wine (true allergy) and not on other wine components or fining agents (other forms of intolerance). A sensitization to grape and wine proteins was observed in our cohort. In one case, this reactivity could be explained by cross-reactivity to CCD. The results of this pilot study need to be validated in greater cohorts. | en_GB |
| dc.description.sponsorship | DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin | de |
| dc.language.iso | eng | de |
| dc.rights | CC BY | * |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | * |
| dc.subject.ddc | 570 Biowissenschaften | de_DE |
| dc.subject.ddc | 570 Life sciences | en_GB |
| dc.title | Assessment of sensitization to grape and wine allergens as possible causes of adverse reactions to wine : a pilot study | en_GB |
| dc.type | Zeitschriftenaufsatz | de |
| dc.identifier.doi | http://doi.org/10.25358/openscience-7389 | - |
| jgu.type.dinitype | article | en_GB |
| jgu.type.version | Published version | de |
| jgu.type.resource | Text | de |
| jgu.organisation.department | FB 04 Medizin | de |
| jgu.organisation.department | FB 10 Biologie | de |
| jgu.organisation.number | 2700 | - |
| jgu.organisation.number | 7970 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | Clinical and translational allergy | de |
| jgu.journal.volume | 5 | de |
| jgu.pages.alternative | Art. 21 | de |
| jgu.publisher.year | 2015 | - |
| jgu.publisher.name | BioMed central | de |
| jgu.publisher.place | London | de |
| jgu.publisher.uri | http://dx.doi.org/10.1186/s13601-015-0065-8 | de |
| jgu.publisher.issn | 2045-7022 | de |
| jgu.organisation.place | Mainz | - |
| jgu.identifier.pmid | 26101585 | |
| jgu.subject.ddccode | 570 | de |
| opus.date.modified | 2018-09-05T09:09:40Z | |
| opus.subject.dfgcode | 00-000 | |
| opus.organisation.string | FB 04: Medizin: Hautklinik | de_DE |
| opus.organisation.string | FB 10: Biologie: Institut für Molekulare Biophysik | de_DE |
| opus.identifier.opusid | 51955 | |
| opus.importsource | pubmed | |
| opus.institute.number | 0431 | |
| opus.institute.number | 1009 | |
| opus.metadataonly | false | |
| opus.type.contenttype | Keine | de_DE |
| opus.type.contenttype | None | en_EN |
| opus.affiliated | Jäckels, Nadine | |
| opus.affiliated | Fronk, Petra | |
| opus.affiliated | Saloga, Joachim | |
| opus.affiliated | Decker, Heinz | |
| jgu.publisher.doi | 10.1186/s13601-015-0065-8 | de |
| jgu.organisation.ror | https://ror.org/023b0x485 | - |
| Appears in collections: | DFG-OA-Publizieren (2012 - 2017) | |
Files in This Item:
| File | Description | Size | Format | ||
|---|---|---|---|---|---|
 | assessment_of_sensitization_t-20220712201241292.pdf | 389.81 kB | Adobe PDF | View/Open |