Authors:	Michal, Matthias Wiltink, Jörg Kirschner, Yvonne Wild, Philipp Münzel, Thomas Ojeda, Francisco M. Zeller, Tanja Schnabel, Renate B. Lackner, Karl J. Blettner, Maria Zwiener, Isabella Beutel, Manfred E.
Title:	Differential associations of depressive symptom dimensions with cardio-vascular disease in the community : results from the gutenberg health study
Online publication date:	12-Jul-2022
Year of first publication:	2013
Language:	english
Abstract:	A current model suggested that the somatic symptom dimension accounts for the adverse effect of depression in patients with coronary heart disease (CHD). In order to test this model we sought to determine in a large population-based sample how symptom dimensions of depression are associated with CHD, biomarkers and traditional risk factors. The associations of cognitive and somatic symptom dimensions of depression with CHD, risk factors, endothelial function, and biomarkers of inflammation and myocardial stress were analyzed cross-sectionally in a sample of n = 5000 Mid-Europeans aged 35-74 years from the Gutenberg Health Study (GHS). Only the somatic symptom dimension of depression was associated with CHD, biomarkers (inflammation, vascular function) and cardio-vascular risk factors. When multivariable adjustment was applied by demographic and cardiovascular risk factors, the weak associations of the somatic symptom dimension with the biomarkers disappeared. However, the associations of the somatic symptom dimension with CHD, myocardial infarction, obesity, dyslipidemia and family history of myocardial infarction remained. Both dimensions of depression were independently associated with a previous diagnosis of depression and distressed personality (type D). Thus, our results partly confirm current models: Somatic, but not cognitive-affective symptom dimensions are responsible for the association between depression and CHD, inflammation, vascular function and cardiovascular risk factors in the general population. However, our findings challenge the assumptions that somatic depression might be due to inflammation or vascular dysfunction as consequence of progressed atherosclerotic disease. They rather emphasize a close interplay with life-style factors and with a family history of MI.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7385
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/3.0/
Journal:	PLoS one 8 8
Pages or article number:	e72014
Publisher:	PLoS
Publisher place:	Lawrence, Kan.
Issue date:	2013
ISSN:	1932-6203
Publisher URL:	http://dx.doi.org/10.1371/journal.pone.0072014
Publisher DOI:	10.1371/journal.pone.0072014
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)