Authors:	Luhmann, Heiko Sinning, Anne Yang, Jenq-Wei Reyes-Puerta, Vicente Stüttgen, Maik C. Kirischuk, Sergei Kilb, Werner
Title:	Spontaneous neuronal activity in developing neocortical networks : from single cells to large-scale cortical interactions
Online publication date:	11-Jul-2022
Year of first publication:	2016
Language:	english
Abstract:	Neuronal activity has been shown to be essential for the proper formation of neuronal circuits, affecting developmental processes like neurogenesis, migration, programmed cell death, cellular differentiation, formation of local and long-range axonal connections, synaptic plasticity or myelination. Accordingly, neocortical areas reveal distinct spontaneous and sensory-driven neuronal activity patterns already at early phases of development. At embryonic stages, when immature neurons start to develop voltage-dependent channels, spontaneous activity is highly synchronized within small neuronal networks and governed by electrical synaptic transmission. Subsequently, spontaneous activity patterns become more complex, involve larger networks and propagate over several neocortical areas. The developmental shift from local to large-scale network activity is accompanied by a gradual shift from electrical to chemical synaptic transmission with an initial excitatory action of chloride-gated channels activated by GABA, glycine and taurine. Transient neuronal populations in the subplate support temporary circuits that play an important role in tuning early neocortical activity and the formation of mature neuronal networks. Thus, early spontaneous activity patterns control the formation of developing networks in sensory cortices, and disturbances of these activity patterns may lead to long-lasting neuronal deficits.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7355
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Frontiers in neural circuits 10
Pages or article number:	Art. 40
Publisher:	Frontiers Research Foundation
Publisher place:	Lausanne
Issue date:	2016
ISSN:	1662-5110
Publisher URL:	http://dx.doi.org/10.3389/fncir.2016.00040
Publisher DOI:	10.3389/fncir.2016.00040
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)