Gutenberg Open Science: Hypoxia tolerance, longevity and cancer-resistance in the mole rat Spalax : a liver transcriptomics approach

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7350

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DC Field	Value	Language
dc.contributor.author	Schmidt, Hanno	-
dc.contributor.author	Malik, Assaf	-
dc.contributor.author	Bicker, Anne	-
dc.contributor.author	Poetzsch, Gesa	-
dc.contributor.author	Avivi, Aaron	-
dc.contributor.author	Shams, Imad	-
dc.contributor.author	Hankeln, Thomas	-
dc.date.accessioned	2022-07-11T10:20:06Z	-
dc.date.available	2022-07-11T10:20:06Z	-
dc.date.issued	2017
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7364	-
dc.description.abstract	The blind subterranean mole rat Spalax shows a remarkable tolerance to hypoxia, cancer-resistance and longevity. Unravelling the genomic basis of these adaptations will be important for biomedical applications. RNA-Seq gene expression data were obtained from normoxic and hypoxic Spalax and rat liver tissue. Hypoxic Spalax broadly downregulates genes from major liver function pathways. This energy-saving response is likely a crucial adaptation to low oxygen levels. In contrast, the hypoxia-sensitive rat shows massive upregulation of energy metabolism genes. Candidate genes with plausible connections to the mole rat’s phenotype, such as important key genes related to hypoxia-tolerance, DNA damage repair, tumourigenesis and ageing, are substantially higher expressed in Spalax than in rat. Comparative liver transcriptomics highlights the importance of molecular adaptations at the gene regulatory level in Spalax and pinpoints a variety of starting points for subsequent functional studies.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Hypoxia tolerance, longevity and cancer-resistance in the mole rat Spalax : a liver transcriptomics approach	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7350	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 10 Biologie	de
jgu.organisation.number	7970	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Scientific reports	de
jgu.journal.volume	7	de
jgu.pages.alternative	Art. 14348	de
jgu.publisher.year	2017	-
jgu.publisher.name	Nature Publ. Group	de
jgu.publisher.place	London	de
jgu.publisher.uri	http://dx.doi.org/10.1038/s41598-017-13905-z	de
jgu.publisher.issn	2045-2322	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2017-11-24T11:43:23Z
opus.subject.dfgcode	00-000
opus.organisation.string	FB 10: Biologie: Institut für Organismische und Molekulare Evolutionsbiologie	de_DE
opus.identifier.opusid	57537
opus.institute.number	1011
opus.metadataonly	false
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Bicker, Anne
opus.affiliated	Hankeln, Thomas
jgu.publisher.doi	10.1038/s41598-017-13905-z	de
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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