Authors:	Michal, Matthias Wiltink, Jörg Kirschner, Yvonne Schneider, Astrid Wild, Philipp Münzel, Thomas Blettner, Maria Schulz, Andreas Lackner, Karl J. Pfeiffer, Norbert Blankenberg, Stefan Tschan, Regine Tuin, Inka Beutel, Manfred E.
Title:	Complaints of sleep disturbances are associated with cardiovascular disease : results from the Gutenberg Health Study
Online publication date:	11-Jul-2022
Year of first publication:	2014
Language:	english
Abstract:	BACKGROUND: Despite their high prevalence, sleep disorders often remain unrecognized and untreated because of barriers to assessment and management. The aims of the present study were to examine associations of complaints of sleep disturbances with cardiovascular disease, related risk factors, and inflammation in the community and to determine the contribution of sleep disturbances to self-perceived physical health. METHOD: The sample consists of n = 10.000 participants, aged 35 to 74 years of a population based community sample in Germany. Cross-sectional associations of complaints of sleep disturbances with cardiovascular risk factors and disease, biomarkers of inflammation, depression, anxiety, and physical health status were analyzed. RESULTS: 19% of our sample endorsed clinically significant sleep disturbances. In the unadjusted analyses severity of sleep disturbances increased with female sex, low socioeconomic status, living without a partnership, cardiovascular disease, depression, anxiety, poor physical health, increased levels of C-reactive protein and fibrinogen. After multivariate adjustment robust associations with coronary heart disease, myocardial infarction and dyslipidemia remained. Complaints of sleep disturbances were strong and independent contributors to self-perceived poor physical health beyond depression, anxiety and medical disease burden. CONCLUSIONS: Given the high prevalence of complaints of sleep disturbances and their strong impact on health status, increased efforts should be undertaken for their identification and treatment.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7344
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	PLoS one 9 8
Pages or article number:	e104324
Publisher:	PLoS
Publisher place:	Lawrence, Kan.
Issue date:	2014
ISSN:	1932-6203
Publisher URL:	http://dx.doi.org/10.1371/journal.pone.0104324
Publisher DOI:	10.1371/journal.pone.0104324
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)