Gutenberg Open Science: SARS-CoV-PLpro-Inhibitoren als mögliche Breitspektrum-Virostatika

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7288

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DC Field	Value	Language
dc.contributor.author	Hammerschmidt, Stefan Josef	-
dc.contributor.author	Müller, Patrick	-
dc.contributor.author	Schirmeister, Tanja	-
dc.date.accessioned	2022-07-04T08:29:48Z	-
dc.date.available	2022-07-04T08:29:48Z	-
dc.date.issued	2021	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7302	-
dc.description.abstract	The SARS-CoV-encoded papain-like cysteine protease (PLpro) plays crucial roles in viral replication and maturation processes. It is required to cleave the precursor polyproteins into functional proteins. Thus, it is considered to be a promising target for developing specific drugs. For rational optimization of hit compounds, information about the structure-activity relationship (SAR) is fundamental. Herein, we characterize isoindolines as a new class of PLpro inhibitors.	en_GB
dc.language.iso	ger	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	SARS-CoV-PLpro-Inhibitoren als mögliche Breitspektrum-Virostatika	de_DE
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7288	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 09 Chemie, Pharmazie u. Geowissensch.	de
jgu.organisation.number	7950	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Biospektrum	de
jgu.journal.volume	27	de
jgu.pages.start	254	de
jgu.pages.end	256	de
jgu.publisher.year	2021	-
jgu.publisher.name	Spektrum	de
jgu.publisher.place	Heidelberg	de
jgu.publisher.issn	1868-6249	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1007/s12268-021-1576-6	de
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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