Gutenberg Open Science: Autophosphorylation and the dynamics of the activation of Lck

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7210

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DC Field	Value	Language
dc.contributor.author	Kreusser, Lisa Maria	-
dc.contributor.author	Rendall, Alan D.	-
dc.date.accessioned	2022-06-27T08:22:27Z	-
dc.date.available	2022-06-27T08:22:27Z	-
dc.date.issued	2021	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7224	-
dc.description.abstract	Lck (lymphocyte-specific protein tyrosine kinase) is an enzyme which plays a number of important roles in the function of immune cells. It belongs to the Src family of kinases which are known to undergo autophosphorylation. It turns out that this leads to a remarkable variety of dynamical behaviour which can occur during their activation. We prove that in the presence of autophosphorylation one phenomenon, bistability, already occurs in a mathematical model for a protein with a single phosphorylation site. We further show that a certain model of Lck exhibits oscillations. Finally, we discuss the relations of these results to models in the literature which involve Lck and describe specific biological processes, such as the early stages of T cell activation and the stimulation of T cell responses resulting from the suppression of PD-1 signalling which is important in immune checkpoint therapy for cancer.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	510 Mathematik	de_DE
dc.subject.ddc	510 Mathematics	en_GB
dc.title	Autophosphorylation and the dynamics of the activation of Lck	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7210	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 08 Physik, Mathematik u. Informatik	de
jgu.organisation.number	7940	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Bulletin of mathematical biology	de
jgu.journal.volume	83	de
jgu.pages.alternative	64	de
jgu.publisher.year	2021	-
jgu.publisher.name	Springer	de
jgu.publisher.place	New York, NY u.a.	de
jgu.publisher.issn	1522-9602	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	510	de
jgu.publisher.doi	10.1007/s11538-021-00900-9	de
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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