Authors:	Kreusser, Lisa Maria Rendall, Alan D.
Title:	Autophosphorylation and the dynamics of the activation of Lck
Online publication date:	27-Jun-2022
Year of first publication:	2021
Language:	english
Abstract:	Lck (lymphocyte-specific protein tyrosine kinase) is an enzyme which plays a number of important roles in the function of immune cells. It belongs to the Src family of kinases which are known to undergo autophosphorylation. It turns out that this leads to a remarkable variety of dynamical behaviour which can occur during their activation. We prove that in the presence of autophosphorylation one phenomenon, bistability, already occurs in a mathematical model for a protein with a single phosphorylation site. We further show that a certain model of Lck exhibits oscillations. Finally, we discuss the relations of these results to models in the literature which involve Lck and describe specific biological processes, such as the early stages of T cell activation and the stimulation of T cell responses resulting from the suppression of PD-1 signalling which is important in immune checkpoint therapy for cancer.
DDC:	510 Mathematik 510 Mathematics
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 08 Physik, Mathematik u. Informatik
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7210
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Bulletin of mathematical biology 83
Pages or article number:	64
Publisher:	Springer
Publisher place:	New York, NY u.a.
Issue date:	2021
ISSN:	1522-9602
Publisher DOI:	10.1007/s11538-021-00900-9
Appears in collections:	JGU-Publikationen