Autoren:	Kreusser, Lisa Maria Rendall, Alan D.
Titel:	Autophosphorylation and the dynamics of the activation of Lck
Online-Publikationsdatum:	27-Jun-2022
Erscheinungsdatum:	2021
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	Lck (lymphocyte-specific protein tyrosine kinase) is an enzyme which plays a number of important roles in the function of immune cells. It belongs to the Src family of kinases which are known to undergo autophosphorylation. It turns out that this leads to a remarkable variety of dynamical behaviour which can occur during their activation. We prove that in the presence of autophosphorylation one phenomenon, bistability, already occurs in a mathematical model for a protein with a single phosphorylation site. We further show that a certain model of Lck exhibits oscillations. Finally, we discuss the relations of these results to models in the literature which involve Lck and describe specific biological processes, such as the early stages of T cell activation and the stimulation of T cell responses resulting from the suppression of PD-1 signalling which is important in immune checkpoint therapy for cancer.
DDC-Sachgruppe:	510 Mathematik 510 Mathematics
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 08 Physik, Mathematik u. Informatik
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7210
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	Bulletin of mathematical biology 83
Seitenzahl oder Artikelnummer:	64
Verlag:	Springer
Verlagsort:	New York, NY u.a.
Erscheinungsdatum:	2021
ISSN:	1522-9602
DOI der Originalveröffentlichung:	10.1007/s11538-021-00900-9
Enthalten in den Sammlungen:	JGU-Publikationen