Authors:	Man, Andy W. C. Xia, Ning Daiber, Andreas Li, Huige
Title:	The roles of gut microbiota and circadian rhythm in the cardiovascular protective effects of polyphenols
Online publication date:	20-Jun-2022
Year of first publication:	2020
Language:	english
Abstract:	Polyphenols are secondary metabolites of plants that have been widely studied for their health benefits as antioxidants. In the last decade, several clinical trials and epidemiological studies have shown that long-term consumption of polyphenol-rich diet protects against chronic diseases such as cancers and cardiovascular diseases. Current cardiovascular studies have also suggested an important role of gut microbiota and circadian rhythm in the pathogenesis metabolic and cardiovascular diseases. It is known that polyphenols can modulate the composition of core gut microbiota and interact with circadian clocks. In this article, we summarize recent findings, review the molecular mechanisms and the potential of polyphenols as dietary supplements for regulating gut microbiota and circadian rhythms, and discuss future research directions.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-7179
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY-NC
Information on rights of use:	https://creativecommons.org/licenses/by-nc/4.0/
Journal:	British journal of pharmacology 177 6
Pages or article number:	1278 1293
Publisher:	Wiley
Publisher place:	Malden, MA
Issue date:	2020
ISSN:	1476-5381
Publisher DOI:	10.1111/bph.14850
Appears in collections:	JGU-Publikationen