Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7172
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dc.contributor.authorSchmidt, Regine-
dc.contributor.authorGraafen, Dirk-
dc.contributor.authorWeber, Stefan-
dc.contributor.authorSchreiber, Laura M.-
dc.date.accessioned2022-06-20T08:17:19Z-
dc.date.available2022-06-20T08:17:19Z-
dc.date.issued2013-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/7186-
dc.description.abstractContrast-enhanced first-pass magnetic resonance imaging (MRI) in combination with a tracer kinetic model, for example, MMID4, can be used to determine myocardial blood flow (MBF) and myocardial perfusion reserve (MPR). Typically, the arterial input function (AIF) required for this methodology is estimated from the left ventricle (LV). Dispersion of the contrast agent bolus might occur between the LV and the myocardial tissue. Negligence of bolus dispersion could cause an error in MBF determination. The aim of this study was to investigate the influence of bolus dispersion in a simplified coronary bifurcation geometry including one healthy and one stenotic branch on the quantification of MBF and MPR. Computational fluid dynamics (CFD) simulations were combined with MMID4. Different inlet boundary conditions describing pulsatile and constant flows for rest and hyperemia and differing outflow conditions have been investigated. In the bifurcation region, the increase of the dispersion was smaller than inside the straight vessels. A systematic underestimation of MBF values up to -16.1% for pulsatile flow and an overestimation of MPR up to 7.5% were found. It was shown that, under the conditions considered in this study, bolus dispersion can significantly influence the results of quantitative myocardial MR-perfusion measurements.en_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizinde
dc.language.isoengde
dc.rightsCC BY*
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/*
dc.subject.ddc500 Naturwissenschaftende_DE
dc.subject.ddc500 Natural sciences and mathematicsen_GB
dc.titleComputational fluid dynamics simulations of contrast agent bolus dispersion in a coronary bifurcation : impact on MRI-Based quantification of myocardial perfusionen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-7172-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleComputational and mathematical methods in medicinede
jgu.journal.volume14de
jgu.pages.alternative513187de
jgu.publisher.year2013-
jgu.publisher.nameHindawide
jgu.publisher.placeNew York, NYde
jgu.publisher.urihttp://dx.doi.org/10.1155/2013/513187de
jgu.publisher.issn1748-6718de
jgu.organisation.placeMainz-
jgu.subject.ddccode500de
opus.date.modified2018-08-02T10:05:57Z-
opus.subject.dfgcode04-205-
opus.organisation.stringFB 04: Medizin: Klinik und Poliklinik für Diagnostische und Interventionelle Radiologiede_DE
opus.identifier.opusid22542-
opus.institute.number0419-
opus.metadataonlyfalse-
opus.type.contenttypeKeinede_DE
opus.type.contenttypeNoneen_EN
opus.affiliatedSchreiber, Laura M.-
jgu.publisher.doi10.1155/2013/513187de
jgu.organisation.rorhttps://ror.org/023b0x485
Appears in collections:DFG-OA-Publizieren (2012 - 2017)

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