Gutenberg Open Science: Antioxidant functions of the aryl hydrocarbon receptor (AhR)

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7166

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DC Field	Value	Language
dc.contributor.author	Dietrich, Cornelia	-
dc.date.accessioned	2022-06-20T07:47:04Z	-
dc.date.available	2022-06-20T07:47:04Z	-
dc.date.issued	2016	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/7180	-
dc.description.abstract	The aryl hydrocarbon receptor (AhR) is a transcription factor belonging to the basic helix-loop-helix/PER-ARNT-SIM family. It is activated by a variety of ligands, such as environmental contaminants like polycyclic aromatic hydrocarbons or dioxins, but also by naturally occurring compounds and endogenous ligands. Binding of the ligand leads to dimerization of the AhR with aryl hydrocarbon receptor nuclear translocator (ARNT) and transcriptional activation of several xenobiotic phase I and phase II metabolizing enzymes. It is generally accepted that the toxic responses of polycyclic aromatic hydrocarbons, dioxins, and structurally related compounds are mediated by activation of the AhR. A multitude of studies indicate that the AhR operates beyond xenobiotic metabolism and exerts pleiotropic functions. Increasing evidence points to a protective role of the AhR against carcinogenesis and oxidative stress. Herein, I will highlight data demonstrating a causal role of the AhR in the antioxidant response and present novel findings on potential AhR-mediated antioxidative mechanisms.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Antioxidant functions of the aryl hydrocarbon receptor (AhR)	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-7166	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Stem cells international	de
jgu.journal.volume	2016	de
jgu.pages.alternative	Art. 7943495	de
jgu.publisher.year	2016	-
jgu.publisher.name	Sage-Hindawi	de
jgu.publisher.place	London u.a.	de
jgu.publisher.uri	http://dx.doi.org/10.1155/2016/7943495	de
jgu.publisher.issn	1687-9678	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
opus.date.modified	2018-08-23T08:53:51Z	-
opus.subject.dfgcode	00-000	-
opus.organisation.string	FB 04: Medizin: Institut für Toxikologie	de_DE
opus.identifier.opusid	56423	-
opus.institute.number	0414	-
opus.metadataonly	false	-
opus.type.contenttype	Keine	de_DE
opus.type.contenttype	None	en_EN
opus.affiliated	Dietrich, Cornelia	-
jgu.publisher.doi	10.1155/2016/7943495	de
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	DFG-OA-Publizieren (2012 - 2017)

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