Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-7123
Authors: | Prochaska, Jürgen H. Frank, Bernd Nagler, Markus Lamparter, Heidrun Weißer, Gerhard Schulz, Andreas Eggebrecht, Lisa Göbel, Sebastian Arnold, Natalie Panova-Noeva, Marina Hermanns, Iris Pinto, Antonio Konstantinides, Stavros ten Cate, Hugo Lackner, Karl J. Münzel, Thomas Espinola-Klein, Christine Wild, Philipp |
Title: | Age-related diagnostic value of D-dimer testing and the role of inflammation in patients with suspected deep vein thrombosis |
Online publication date: | 13-Jun-2022 |
Year of first publication: | 2017 |
Language: | english |
Abstract: | Previous reports have investigated the impact of age on D-Dimer testing in elderly individuals with suspected deep vein thrombosis (DVT), but data on the age-related diagnostic value of D-dimer in a sample covering a broad age range are limited. The present study determined age-specifically the diagnostic accuracy of D-dimer and compared it to C-reactive protein (CRP), a marker of inflammation, in 500 patients with suspected DVT from the VTEval project (NCT02156401). Sensitivity of D-dimer was lower in patients < 60 years in comparison to patients ≥ 60 years (∆−16.8%), whereas specificity was 27.9% higher. Lowest levels of sensitivity were detected for female sex, unprovoked DVT, low thrombotic burden, and distal DVT. A fixed D-dimer threshold of 0.25 mg/L FEU resulted in elevated sensitivity for patients < 60 with a reduction of false negatives by 40.0% for proximal DVT and by 50.0% for distal DVT. In patients < 60 years, D-dimer and CRP demonstrated comparable diagnostic performance for both proximal and distal DVT (p > 0.05). In conclusion, these data outline a clinically-relevant limitation of D-dimer testing among younger patients with suspected DVT indicating a necessity for age-adapted cut-off values. Further research is required to decrypt the role of inflammation in the pathophysiology and diagnosis of venous thrombosis. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-7123 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Scientific reports 7 |
Pages or article number: | Art. 4591 |
Publisher: | Macmillan Publishers Limited, part of Springer Nature |
Publisher place: | London |
Issue date: | 2017 |
ISSN: | 2045-2322 |
Publisher URL: | http://dx.doi.org/10.1038/s41598-017-04843-x |
Publisher DOI: | 10.1038/s41598-017-04843-x |
Appears in collections: | DFG-OA-Publizieren (2012 - 2017) |
Files in This Item:
File | Description | Size | Format | ||
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agerelated_diagnostic_value_o-20220612152838630.pdf | 2.41 MB | Adobe PDF | View/Open |