Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-7096
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dc.contributor.authorBarco, Stefano-
dc.contributor.authorKlok, Frederikus A.-
dc.contributor.authorKonstantinides, Stavros V.-
dc.contributor.authorDartevelle, Philippe-
dc.contributor.authorFadel, Elie-
dc.contributor.authorJenkins, David-
dc.contributor.authorKim, Nick H.-
dc.contributor.authorMadani, Michael-
dc.contributor.authorMatsubara, Hiromi-
dc.contributor.authorMayer, Eckhard-
dc.contributor.authorPepke-Zaba, Joanna-
dc.contributor.authorSimonneau, Gérard-
dc.contributor.authorDelcroix, Marion-
dc.contributor.authorLang, Irene M.-
dc.date.accessioned2022-06-08T10:02:40Z-
dc.date.available2022-06-08T10:02:40Z-
dc.date.issued2020-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/7110-
dc.description.abstractBACKGROUND Women are more susceptible than men to several forms of pulmonary hypertension, but have better survival. Sparse data are available on chronic thromboembolic pulmonary hypertension (CTEPH). METHODS We investigated sex-specific differences in the clinical presentation of CTEPH, performance of pulmonary endarterectomy (PEA), and survival. RESULTS Women constituted one-half of the study population of the European CTEPH registry (N = 679) and were characterized by a lower prevalence of some cardiovascular risk factors, including prior acute coronary syndrome, smoking habit, and chronic obstructive pulmonary disease, but more prevalent obesity, cancer, and thyroid diseases. The median age was 62 (interquartile ratio, 50-73) years in women and 63 (interquartile ratio, 53-70) in men. Women underwent PEA less often than men (54% vs 65%), especially at low-volume centers (48% vs 61%), and were exposed to fewer additional cardiac procedures, notably coronary artery bypass graft surgery (0.5% vs 9.5%). The prevalence of specific reasons for not being operated, including patient′s refusal and the proportion of proximal vs distal lesions, did not differ between sexes. A total of 57 (17.0%) deaths in women and 70 (20.7%) in men were recorded over long-term follow-up. Female sex was positively associated with long-term survival (adjusted hazard ratio, 0.66; 95% confidence interval, 0.46-0.94). Short-term mortality was identical in the two groups. CONCLUSIONS Women with CTEPH underwent PEA less frequently than men, especially at low-volume centers. Furthermore, they had a lower prevalence of cardiovascular risk factors and were less often exposed to additional cardiac surgery procedures. Women had better long-term survival.en_GB
dc.language.isoengde
dc.rightsCC BY-NC*
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/*
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleSex-specific differences in chronic thromboembolic pulmonary hypertension : results from the European CTEPH registryen_GB
dc.typeZeitschriftenaufsatzde
dc.identifier.doihttp://doi.org/10.25358/openscience-7096-
jgu.type.dinitypearticleen_GB
jgu.type.versionPublished versionde
jgu.type.resourceTextde
jgu.organisation.departmentFB 04 Medizinde
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleJournal of thrombosis and haemostasisde
jgu.journal.volume18de
jgu.journal.issue1de
jgu.pages.start151de
jgu.pages.end161de
jgu.publisher.year2020-
jgu.publisher.nameWiley-Blackwellde
jgu.publisher.placeOxfordde
jgu.publisher.issn1538-7836de
jgu.organisation.placeMainz-
jgu.subject.ddccode610de
jgu.publisher.doi10.1111/jth.14629de
jgu.organisation.rorhttps://ror.org/023b0x485
Appears in collections:JGU-Publikationen

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