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Autoren: Hopf, Susanne
Schwantuschke, Doris
Schmidtmann, Irene
Pfeiffer, Norbert
Hoffmann, Esther Maria
Titel: Impact of intraocular pressure fluctuations on progression of normal tension glaucoma
Online-Publikationsdatum: 21-Jan-2022
Erscheinungsdatum: 2021
Sprache des Dokuments: Englisch
Zusammenfassung/Abstract: AIM: To investigate short- and long-term intraocular pressure (IOP) fluctuations and further ocular and demographic parameters as predictors for normal tension glaucoma (NTG) progression. METHODS: This retrospective, longitudinal cohort study included 137 eyes of 75 patients with NTG, defined by glaucomatous optic disc or visual field defect with normal IOP (<21 mm Hg), independently from therapy regimen. IOP fluctuation, mean, and maximum were inspected with a mean follow-up of 38mo [standard deviation (SD) 18mo]. Inclusion criteria were the performance of minimum two 48-hour profiles including perimetry, Heidelberg retina tomograph (HRT) imaging, and optic disc photographs. The impact of IOP parameters, myopia, sex, cup-to-disc-ratio, and visual field results on progression of NTG were analyzed using Cox regression models. A sub-group analysis with results from optical coherence tomography (OCT) was performed. RESULTS: IOP fluctuations, average, and maximum were not risk factors for progression in NTG patients, although maximum IOP at the initial IOP profile was higher in eyes with progression than in eyes without progression (P=0.054). The 46/137 (33.5%) eyes progressed over the follow-up period. Overall progression (at least three progression confirmations) occurred in 28/137 eyes (20.4%). Most progressions were detected by perimetry (36/46). Long-term IOP mean over all pressure profiles was 12.8 mm Hg (SD 1.3 mm Hg); IOP fluctuation was 1.4 mm Hg (SD 0.8 mm Hg). The progression-free five-year rate was 58.2% (SD 6.5%). CONCLUSION: Short- and long-term IOP fluctuations do not result in progression of NTG. As functional changes are most likely to happen, NTG should be monitored with visual field testing more often than with other devices. Keywords: intraocular pressure intraocular pressure fluctuation glaucoma progression visual field optical optical coherence tomography
DDC-Sachgruppe: 610 Medizin
610 Medical sciences
Veröffentlichende Institution: Johannes Gutenberg-Universität Mainz
Organisationseinheit: FB 04 Medizin
Veröffentlichungsort: Mainz
ROR: https://ror.org/023b0x485
DOI: http://doi.org/10.25358/openscience-6710
Version: Published version
Publikationstyp: Zeitschriftenaufsatz
Weitere Angaben zur Dokumentart: Scientific article
Nutzungsrechte: CC BY-NC-ND
Informationen zu den Nutzungsrechten: https://creativecommons.org/licenses/by-nc-nd/4.0/
Zeitschrift: International Journal of Ophthalmology
14
10
Seitenzahl oder Artikelnummer: 1553
1559
Verlag: IJO Press
Verlagsort: Xi'an
Erscheinungsdatum: 2021
ISSN: 2227-4898
2222-3959
URL der Originalveröffentlichung: https://doi.org/10.18240/ijo.2021.10.12
DOI der Originalveröffentlichung: 10.18240/ijo.2021.10.12
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