Gutenberg Open Science: Hyperspectral imaging to study dynamic skin perfusion after injection of Articaine-4% with and without epinephrine : clinical implications on local vasoconstriction

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-6445

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DC Field	Value	Language
dc.contributor.author	Thiem, Daniel G. E.	-
dc.contributor.author	Hans, Lukas	-
dc.contributor.author	Blatt, Sebastian	-
dc.contributor.author	Römer, Paul	-
dc.contributor.author	Heimes, Diana	-
dc.contributor.author	Al-Nawas, Bilal	-
dc.contributor.author	Kämmerer, Peer W.	-
dc.date.accessioned	2021-11-05T08:20:46Z	-
dc.date.available	2021-11-05T08:20:46Z	-
dc.date.issued	2021	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/6455	-
dc.description.abstract	This study aimed to investigate the dynamic skin perfusion via hyperspectral imaging (HSI) after application of Articaine-4% ± epinephrine as well as epinephrine only. After the subcutaneous injection of (A100) Articaine-4% with epinephrine 1:100,000, (A200) Articaine-4% with epinephrine 1:200,000, (Aw/o) Articaine-4% without epinephrine, and (EPI200) epinephrine 1:200,000, into the flexor side of the forearm in a split-arm design, dynamic skin perfusion measurement was performed over 120 min by determining tissue oxygen saturation (StO2) using HSI. After injection, all groups experienced a reactive hyperaemia. With A200, it took about three min for StO2 to drop below baseline. For Aw/o and EPI200, perfusion reduction when compared to baseline was seen at 30 min with vasoconstriction >120 min. A100 caused vasodilation with hyperaemia >60 min. After three minutes, the perfusion pattern differed significantly (p < 0.001) between all groups except Aw/o and EPI200. The vasoactive effect of epinephrine-containing local anaesthetics can be visualised and dynamically quantified via StO2 using HSI. Aw/o + epinephrine 1:100,000 and 1:200,000 leads to perfusion reduction and tissue ischaemia after 30 min, which lasts over 120 min with no significant difference between both formulations. When using Aw/o containing epinephrine in terms of haemostasis for surgical procedures, a prolonged waiting time before incision of 30 or more min can be recommended.	en_GB
dc.description.sponsorship	Open Access-Publizieren Universität Mainz / Universitätsmedizin Mainz	de
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Hyperspectral imaging to study dynamic skin perfusion after injection of Articaine-4% with and without epinephrine : clinical implications on local vasoconstriction	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-6445	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Journal of Clinical Medicine	de
jgu.journal.volume	10	de
jgu.journal.issue	15	de
jgu.pages.alternative	3411	de
jgu.publisher.year	2021	-
jgu.publisher.name	MDPI	de
jgu.publisher.place	Basel	de
jgu.publisher.uri	https://doi.org/10.3390/jcm10153411	de
jgu.publisher.issn	2077-0383	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.3390/jcm10153411
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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