Authors:	Ewald, Johannes Blankenburg, Jan Worm, Matthias Besch, Laura Unger, Ronald E. Tremel, Wolfgang Frey, Holger Pohlit, Hannah
Title:	Acid-cleavable poly(ethylene glycol) hydrogels displaying protein release at pH 5
Online publication date:	3-Aug-2021
Year of first publication:	2020
Language:	english
Abstract:	PEG is the gold standard polymer for pharmaceutical applications, however it lacks degradability. Degradation under physiologically relevant pH as present in endolysosomes, cancerous and inflammatory tissues is crucial for many areas. The authors present anionic ring-opening copolymerization of ethylene oxide with 3,4-epoxy-1-butene (EPB) and subsequent modification to introduce acid-degradable vinyl ether groups as well as methacrylate (MA) units, enabling radical cross-linking. Copolymers with different molar ratios of EPB, molecular weights (Mn) up to 10 000 g mol−1 and narrow dispersities (Đ<1.05) were prepared. Both the P(EG-co-isoEPB)MA copolymer and the hydrogels showed pH-dependent, rapid hydrolysis at pH 5–6 and long-term storage stability at neutral pH (pH 7.4). By designing the degree of polymerization and content of degradable vinyl ether groups, the release time of an entrapped protein OVA-Alexa488 can be tailored from a few hours to several days (hydrolysis half-life time t1/2 at pH 5: 13 h to 51 h).
DDC:	540 Chemie 540 Chemistry and allied sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 09 Chemie, Pharmazie u. Geowissensch.
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-6236
Version:	Published version
Publication type:	Zeitschriftenaufsatz
License:	CC BY-NC
Information on rights of use:	https://creativecommons.org/licenses/by-nc/4.0/
Journal:	Chemistry - a European journal 26 13
Pages or article number:	2947 2953
Publisher:	Wiley-VCH
Publisher place:	Weinheim
Issue date:	2020
ISSN:	1521-3765
Publisher URL:	https://doi.org/10.1002/chem.201905310
Publisher DOI:	10.1002/chem.201905310
Appears in collections:	JGU-Publikationen