Gutenberg Open Science: Alzheimer's disease in the gut : major changes in the gut of 5xFAD model mice with ApoA1 as potential key player

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-6167

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DC Field	Value	Language
dc.contributor.author	Stoye, Nicolai M.	-
dc.contributor.author	Santos Guilherme, Malena dos	-
dc.contributor.author	Endres, Kristina	-
dc.date.accessioned	2021-07-05T08:30:53Z	-
dc.date.available	2021-07-05T08:30:53Z	-
dc.date.issued	2020	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/6176	-
dc.description.abstract	Alzheimer's disease (AD) affects around 33 million people worldwide, which makes it the most prominent form of dementia. The main focus of AD research has been on the central nervous system (CNS) for long, but in recent years, the gut gained more attention. The intestinal tract is innervated by the enteric nervous system (ENS), built of numerous different types of neurons showing great similarity to neurons of the CNS. It already has been demonstrated that the amyloid precursor protein, which plays a major role in AD pathology, is also expressed in these cells. We analyzed gut tissue of AD model mice (5xFAD) and the respective wild-type littermates at different pathological stages: pre-pathological, early pathological and late pathological. Our results show significant difference in function of the intestine of 5xFAD mice as compared to wild-type mice. Using a pathway array detecting 84 AD-related gene products, we found ApoA1 expression significantly altered in colon tissue of 5xFAD mice. Furthermore, we unveil ApoA1's beneficial impact on cell viability and calcium homeostasis of cultured enteric neurons of 5xFAD animals. With this study, we demonstrate that the intestine is altered in AD-like pathology and that ApoA1 might be one key player within the gut.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY-NC	*
dc.rights.uri	https://creativecommons.org/licenses/by-nc/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Alzheimer's disease in the gut : major changes in the gut of 5xFAD model mice with ApoA1 as potential key player	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-6167	-
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	The FASEB journal	de
jgu.journal.volume	34	de
jgu.journal.issue	9	de
jgu.pages.start	11883	de
jgu.pages.end	11899	de
jgu.publisher.year	2020	-
jgu.publisher.name	Wiley	de
jgu.publisher.place	Hoboken, NJ	de
jgu.publisher.uri	https://doi.org/10.1096/fj.201903128RR	de
jgu.publisher.issn	1530-6860	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1096/fj.201903128RR
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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