Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-5907
Authors: | Krebs, Franziska K. Trzeciak, Emily R. Zimmer, Sophia Özistanbullu, Deniz Mitzel-Rink, Heidrun Meissner, Markus Grabbe, Stephan Loquai, Carmen Tüttenberg, Andrea |
Title: | Immune signature as predictive marker for response to checkpoint inhibitor immunotherapy and overall survival in melanoma |
Online publication date: | 12-May-2021 |
Year of first publication: | 2021 |
Language: | english |
Abstract: | BACKGROUND Malignant melanoma is an immunogenic skin cancer with an increasing global incidence. Advanced stages of melanoma have poor prognoses. Currently, there are no reliable parameters to predict a patient's response to immune checkpoint inhibitor (ICI) therapy. METHODS This study highlights the relevance of a distinct immune signature in the blood for response to ICI therapy and overall survival (OS). Therefore, the immune cell composition in the peripheral blood of 45 melanoma patients prior to ICI therapy was analyzed by flow cytometry and complete blood count. RESULTS Responders to ICI therapy displayed an abundance of proliferating CD4+ T cells, an increased lymphocyte‐to‐monocyte ratio, a low platelet‐to‐lymphocyte ratio, low levels of CTLA‐4+ Treg, and (arginase 1+) polymorphonuclear myeloid‐derived suppressor cells (PMN‐MDSC). Nevertheless, non‐responders with similar immune cell compositions also benefited from therapy displaying increased long‐term OS. CONCLUSION Our study demonstrated that the observed immune signature in the peripheral blood of melanoma patients prior to treatment could identify responders as well as non‐responders that benefit from ICI immunotherapies. |
DDC: | 610 Medizin 610 Medical sciences |
Institution: | Johannes Gutenberg-Universität Mainz |
Department: | FB 04 Medizin |
Place: | Mainz |
ROR: | https://ror.org/023b0x485 |
DOI: | http://doi.org/10.25358/openscience-5907 |
Version: | Published version |
Publication type: | Zeitschriftenaufsatz |
License: | CC BY |
Information on rights of use: | https://creativecommons.org/licenses/by/4.0/ |
Journal: | Cancer medicine 10 5 |
Pages or article number: | 1562 1575 |
Publisher: | Wiley |
Publisher place: | Hoboken, NJ |
Issue date: | 2021 |
ISSN: | 2045-7634 |
Publisher URL: | https://doi.org/10.1002/cam4.3710 |
Publisher DOI: | 10.1002/cam4.3710 |
Appears in collections: | JGU-Publikationen |
Files in This Item:
File | Description | Size | Format | ||
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krebs_franziska_k.-immune_signatu-20210512105700368.pdf | 1.29 MB | Adobe PDF | View/Open |