Gutenberg Open Science: Genetic findings in miscarriages and their relation to the number of previous miscarriages

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-5806

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DC Field	Value	Language
dc.contributor.author	Gomez, Ruth	-
dc.contributor.author	Hafezi, N.	-
dc.contributor.author	Amrani, M.	-
dc.contributor.author	Schweiger, Susann	-
dc.contributor.author	Dewenter, Malin K.	-
dc.contributor.author	Thomas, Petra	-
dc.contributor.author	Lieb, C.	-
dc.contributor.author	Hasenburg, Annette	-
dc.contributor.author	Skala, Christine	-
dc.date.accessioned	2021-05-10T08:47:08Z	-
dc.date.available	2021-05-10T08:47:08Z	-
dc.date.issued	2021	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/5815	-
dc.description.abstract	PURPOSE Early pregnancy loss leads to a devastating situation for many couples. Genetic disorders found in the pregnancy tissue are a frequent cause of miscarriages. It is unclear whether maternal age or previous miscarriages are associated with a higher chromosomal anomaly rate. This study aimed to determine the cytogenetical distribution of chromosomal disorders in couples after one or more previous miscarriages as well as the influence of maternal age. METHODS 406 fetal tissue samples obtained after spontaneous abortion between 2010 and 2014 were successfully karyotyped. This included 132 couples with at least two losses and 274 couples with sporadic miscarriage. Normal and abnormal karyotype rate was determined for age, parity, gravidity, gestational week and number of previous miscarriages by logistic regression analysis. RESULTS 145 (35.71%) fetal tissue samples had a normal karyotype, and 261 (64.8%) did not. After adjusting for age, older patients have a statistically significantly higher probability of genetic disorders in the pregnancy tissue (p < 0.001, OR 1.064, 95% CI 1.03–1.11). With each additional year, the probability of finding chromosomal abnormalities in a miscarriage increased by 6.4%. Patients younger than 35 years have a lower probability of having chromosomal disorders in the aborted material after two or more miscarriages than after sporadic miscarriages (50.7 vs. 58.9%) (p = 0.014, OR 0.67, 95% CI 0.48–0.914). Nevertheless, the risk of embryonic chromosomal disorders in patients aged 35 and above increased from 75.5% in sporadic miscarriages to 82.4% after more than one pregnancy losses (p = 0.59, OR 1.14, 95% CI − 0.72 to 1.92). CONCLUSION Chromosomal disorders found after one or more previous miscarriages are related to patients’ age. Couples suffering two or more miscarriages should be further researched, especially in younger patients.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Genetic findings in miscarriages and their relation to the number of previous miscarriages	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-5806	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Archives of gynecology and obstetrics	de
jgu.journal.volume	303	de
jgu.pages.start	1425	de
jgu.pages.end	1432	de
jgu.publisher.year	2021	-
jgu.publisher.name	Springer	de
jgu.publisher.place	Berlin u.a.	de
jgu.publisher.uri	https://doi.org/10.1007/s00404-020-05859-x	de
jgu.publisher.issn	1432-0711	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1007/s00404-020-05859-x
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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