Gutenberg Open Science: Dietary wheat amylase trypsin inhibitors impact Alzheimer’s disease pathology in 5xFAD model mice

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-5509

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DC Field	Value	Language
dc.contributor.author	Santos Guilherme, Malena dos	-
dc.contributor.author	Zevallos, Victor F.	-
dc.contributor.author	Pesi, Aline	-
dc.contributor.author	Stoye, Nicolai M.	-
dc.contributor.author	Nguyen, Vu Thu Thuy	-
dc.contributor.author	Radyushkin, Konstantin	-
dc.contributor.author	Schwiertz, Andreas	-
dc.contributor.author	Schmitt, Ulrich	-
dc.contributor.author	Schuppan, Detlef	-
dc.contributor.author	Endres, Kristina	-
dc.date.accessioned	2020-12-18T10:22:02Z	-
dc.date.available	2020-12-18T10:22:02Z	-
dc.date.issued	2020	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/5513	-
dc.description.abstract	Wheat amylase trypsin inhibitors (ATIs) represent a common dietary protein component of gluten-containing cereals (wheat, rye, and barley). They act as toll-like receptor 4 ligands, and are largely resistant to intestinal proteases, eliciting a mild inflammatory response within the intestine after oral ingestion. Importantly, nutritional ATIs exacerbated inflammatory bowel disease and features of fatty liver disease and the metabolic syndrome in mice. For Alzheimer’s disease (AD), both inflammation and altered insulin resistance are major contributing factors, impacting onset as well as progression of this devastating brain disorder in patients. In this study, we evaluated the impact of dietary ATIs on a well-known rodent model of AD (5xFAD). We assessed metabolic, behavioral, inflammatory, and microbial changes in mice consuming different dietary regimes with and without ATIs, consumed ad libitum for eight weeks. We demonstrate that ATIs, with or without a gluten matrix, had an impact on the metabolism and gut microbiota of 5xFAD mice, aggravating pathological hallmarks of AD. If these findings can be translated to patients, an ATI-depleted diet might offer an alternative therapeutic option for AD and warrants clinical intervention studies. Keywords: Aβ ATI 5xFAD gluten inflammation intestine	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin Mainz	de
dc.language.iso	eng	de
dc.rights	CC BY	de_DE
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	-
dc.subject.ddc	540 Chemie	de_DE
dc.subject.ddc	540 Chemistry and allied sciences	en_GB
dc.subject.ddc	570 Biowissenschaften	de_DE
dc.subject.ddc	570 Life sciences	en_GB
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Dietary wheat amylase trypsin inhibitors impact Alzheimer’s disease pathology in 5xFAD model mice	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-5509	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	International journal of molecular sciences	de
jgu.journal.volume	21	de
jgu.journal.issue	17	de
jgu.pages.alternative	6288	de
jgu.publisher.year	2020	-
jgu.publisher.name	MDPI	de
jgu.publisher.place	Basel	de
jgu.publisher.uri	https://doi.org/10.3390/ijms21176288	de
jgu.publisher.issn	1422-0067	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	540	de
jgu.subject.ddccode	570	de
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.3390/ijms21176288
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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