Gutenberg Open Science: The effect of endothelial progenitor cells on the migration ability of different cell lines of head and neck squamous cell carcinoma

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-5368

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DC Field	Value	Language
dc.contributor.author	Rachele Righesso, Leonardo Augusto	-
dc.date.accessioned	2020-12-16T14:24:34Z	-
dc.date.available	2020-12-16T14:24:34Z	-
dc.date.issued	2020	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/5372	-
dc.description.abstract	EPCs can induce, in adult life, the formation of new blood vessels through a de novo production of endothelial cells. This process can occur in physiological and pathological states, and it is usually triggered by ischemia. EPC-induced vasculogenesis is essential for tumor growth and metastasis; hence, it is a valuable therapeutic target. However, due to the development of resistance, the effect of current anti-angiogenic medications tends to be transitory. In order to create new treatments that more effectively target EPCs, it is imperative to better understand the mechanisms involved in tumor vessel formation, and how EPCs contribute to tumor progression and metastasis. With this in mind, we aimed to investigate the effect of different concentrations of EPCs or their supernatant on the migration ability of four different HNSCC cell lines: PCI-1, PCI-13, SCC-4 and SCC-68. We found that, at low concentrations (0,01% and 0,01%), the higher the supernatant’s concentration, the greater the influence on SCC-68 cells mobility. However, when analyzing our results, it must be taken into consideration the difficulty to identify and characterize EPCs, which can lead to an overestimation of their numbers and effect. Moreover, our study is limited by its small sample size. Therefore, further studies with larger sample sizes are needed to confirm our findings.	en_GB
dc.language.iso	eng	de
dc.rights	CC BY	*
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/deed.en	*
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	The effect of endothelial progenitor cells on the migration ability of different cell lines of head and neck squamous cell carcinoma	en_GB
dc.title.alternative	Die Auswirkung endothelialer Progenitorzellen auf die Migrationsfähigkeit verschiedener Zelllinien des Plattenepithelkarzinoms des Kopf-Hals-Bereichs	de_DE
dc.type	Dissertation	de
dc.identifier.urn	urn:nbn:de:hebis:77-openscience-910d7bd9-df5d-45c7-8a57-86cd983913990	-
dc.identifier.doi	http://doi.org/10.25358/openscience-5368	-
jgu.type.dinitype	doctoralThesis	en_GB
jgu.type.version	Original work	de
jgu.type.resource	Text	de
jgu.date.accepted	2020-12-08	-
jgu.description.extent	68 Seiten	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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