Gutenberg Open Science: Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort

Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-5217

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DC Field	Value	Language
dc.contributor.author	Rezapour, Jasmin	-
dc.contributor.author	Schuster, Alexander K.	-
dc.contributor.author	Nickels, Stefan	-
dc.contributor.author	Korb, Christina A.	-
dc.contributor.author	Elbaz, Hisham	-
dc.contributor.author	Peto, Tunde	-
dc.contributor.author	Michal, Matthias	-
dc.contributor.author	Münzel, Thomas	-
dc.contributor.author	Wild, Philipp S.	-
dc.contributor.author	König, Jochem	-
dc.contributor.author	Lackner, Karl	-
dc.contributor.author	Schulz, Andreas	-
dc.contributor.author	Pfeiffer, Norbert	-
dc.contributor.author	Beutel, Manfred E.	-
dc.date.accessioned	2020-10-26T09:02:44Z	-
dc.date.available	2020-10-26T09:02:44Z	-
dc.date.issued	2020	-
dc.identifier.uri	https://openscience.ub.uni-mainz.de/handle/20.500.12030/5221	-
dc.description.abstract	To investigate the prevalence and new onset of depression and anxiety among subjects with agerelated macular degeneration (AMD) and its association with AMD in a large European cohort with relatively good visual acuity. 11,834 participants enrolled in the German population-based Gutenberg Health Study were studied. AMD was diagnosed by grading of fundus photographs. Depression and anxiety were assessed with the Patient Health Questionnaire and the Generalized Anxiety Disorder-2 Scale, respectively. Logistic regression analyses were performed and adjusted for several parameters. 1,089 (9.2%) participants were diagnosed having AMD. Prevalence of depression in AMD and non-AMD participants was 7.2% and 8.0%, respectively and prevalence of anxiety was 4.2% and 7.0%, respectively. New onset of depression and anxiety at 5-year follow-up in AMD subjects was 2.6% and 3.6%, respectively. AMD was not associated with depression (OR 0.93; CI 95% 0.70–1.20; p = 0.62). AMD was associated with less anxiety (OR 0.67; CI 95% 0.47–0.93; p = 0.02). This is the first study analyzing both prevalence and new onset of depression and anxiety in AMD subjects. AMD- and non-AMD participants had a similar prevalence and new onset of depression in our population-based sample. Participants without AMD had a higher prevalence of anxiety. AMD was not associated with depression.	en_GB
dc.description.sponsorship	DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin	de
dc.language.iso	eng	de
dc.rights	CC BY	-
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	-
dc.subject.ddc	610 Medizin	de_DE
dc.subject.ddc	610 Medical sciences	en_GB
dc.title	Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort	en_GB
dc.type	Zeitschriftenaufsatz	de
dc.identifier.doi	http://doi.org/10.25358/openscience-5217	-
jgu.type.contenttype	Scientific article	de
jgu.type.dinitype	article	en_GB
jgu.type.version	Published version	de
jgu.type.resource	Text	de
jgu.organisation.department	FB 04 Medizin	de
jgu.organisation.number	2700	-
jgu.organisation.name	Johannes Gutenberg-Universität Mainz	-
jgu.rights.accessrights	openAccess	-
jgu.journal.title	Scientific Reports	de
jgu.journal.volume	10	de
jgu.pages.alternative	Art. 4816	de
jgu.publisher.year	2020	-
jgu.publisher.name	Macmillan Publishers Limited, part of Springer Nature	de
jgu.publisher.place	London	de
jgu.publisher.uri	https://doi.org/10.1038/s41598-020-61706-8	de
jgu.publisher.issn	2045-2322	de
jgu.organisation.place	Mainz	-
jgu.subject.ddccode	610	de
jgu.publisher.doi	10.1038/s41598-020-61706-8
jgu.organisation.ror	https://ror.org/023b0x485
Appears in collections:	JGU-Publikationen

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