Authors:	Rezapour, Jasmin Schuster, Alexander K. Nickels, Stefan Korb, Christina A. Elbaz, Hisham Peto, Tunde Michal, Matthias Münzel, Thomas Wild, Philipp S. König, Jochem Lackner, Karl Schulz, Andreas Pfeiffer, Norbert Beutel, Manfred E.
Title:	Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort
Online publication date:	26-Oct-2020
Year of first publication:	2020
Language:	english
Abstract:	To investigate the prevalence and new onset of depression and anxiety among subjects with agerelated macular degeneration (AMD) and its association with AMD in a large European cohort with relatively good visual acuity. 11,834 participants enrolled in the German population-based Gutenberg Health Study were studied. AMD was diagnosed by grading of fundus photographs. Depression and anxiety were assessed with the Patient Health Questionnaire and the Generalized Anxiety Disorder-2 Scale, respectively. Logistic regression analyses were performed and adjusted for several parameters. 1,089 (9.2%) participants were diagnosed having AMD. Prevalence of depression in AMD and non-AMD participants was 7.2% and 8.0%, respectively and prevalence of anxiety was 4.2% and 7.0%, respectively. New onset of depression and anxiety at 5-year follow-up in AMD subjects was 2.6% and 3.6%, respectively. AMD was not associated with depression (OR 0.93; CI 95% 0.70–1.20; p = 0.62). AMD was associated with less anxiety (OR 0.67; CI 95% 0.47–0.93; p = 0.02). This is the first study analyzing both prevalence and new onset of depression and anxiety in AMD subjects. AMD- and non-AMD participants had a similar prevalence and new onset of depression in our population-based sample. Participants without AMD had a higher prevalence of anxiety. AMD was not associated with depression.
DDC:	610 Medizin 610 Medical sciences
Institution:	Johannes Gutenberg-Universität Mainz
Department:	FB 04 Medizin
Place:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-5217
Version:	Published version
Publication type:	Zeitschriftenaufsatz
Document type specification:	Scientific article
License:	CC BY
Information on rights of use:	https://creativecommons.org/licenses/by/4.0/
Journal:	Scientific Reports 10
Pages or article number:	Art. 4816
Publisher:	Macmillan Publishers Limited, part of Springer Nature
Publisher place:	London
Issue date:	2020
ISSN:	2045-2322
Publisher URL:	https://doi.org/10.1038/s41598-020-61706-8
Publisher DOI:	10.1038/s41598-020-61706-8
Appears in collections:	JGU-Publikationen