Autoren:	Rezapour, Jasmin Schuster, Alexander K. Nickels, Stefan Korb, Christina A. Elbaz, Hisham Peto, Tunde Michal, Matthias Münzel, Thomas Wild, Philipp S. König, Jochem Lackner, Karl Schulz, Andreas Pfeiffer, Norbert Beutel, Manfred E.
Titel:	Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort
Online-Publikationsdatum:	26-Okt-2020
Erscheinungsdatum:	2020
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	To investigate the prevalence and new onset of depression and anxiety among subjects with agerelated macular degeneration (AMD) and its association with AMD in a large European cohort with relatively good visual acuity. 11,834 participants enrolled in the German population-based Gutenberg Health Study were studied. AMD was diagnosed by grading of fundus photographs. Depression and anxiety were assessed with the Patient Health Questionnaire and the Generalized Anxiety Disorder-2 Scale, respectively. Logistic regression analyses were performed and adjusted for several parameters. 1,089 (9.2%) participants were diagnosed having AMD. Prevalence of depression in AMD and non-AMD participants was 7.2% and 8.0%, respectively and prevalence of anxiety was 4.2% and 7.0%, respectively. New onset of depression and anxiety at 5-year follow-up in AMD subjects was 2.6% and 3.6%, respectively. AMD was not associated with depression (OR 0.93; CI 95% 0.70–1.20; p = 0.62). AMD was associated with less anxiety (OR 0.67; CI 95% 0.47–0.93; p = 0.02). This is the first study analyzing both prevalence and new onset of depression and anxiety in AMD subjects. AMD- and non-AMD participants had a similar prevalence and new onset of depression in our population-based sample. Participants without AMD had a higher prevalence of anxiety. AMD was not associated with depression.
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-5217
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Weitere Angaben zur Dokumentart:	Scientific article
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	Scientific Reports 10
Seitenzahl oder Artikelnummer:	Art. 4816
Verlag:	Macmillan Publishers Limited, part of Springer Nature
Verlagsort:	London
Erscheinungsdatum:	2020
ISSN:	2045-2322
URL der Originalveröffentlichung:	https://doi.org/10.1038/s41598-020-61706-8
DOI der Originalveröffentlichung:	10.1038/s41598-020-61706-8
Enthalten in den Sammlungen:	JGU-Publikationen