Please use this identifier to cite or link to this item:
http://doi.org/10.25358/openscience-378Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Mier, Pablo | - |
| dc.contributor.author | Andrade, Miguel | - |
| dc.date.accessioned | 2018-05-18T08:15:26Z | - |
| dc.date.available | 2018-05-18T10:15:26Z | - |
| dc.date.issued | 2018 | - |
| dc.identifier.uri | https://openscience.ub.uni-mainz.de/handle/20.500.12030/380 | - |
| dc.description.abstract | Amino acid usage in a proteome depends mostly on its taxonomy, as it does the codon usage in transcriptomes. Here, we explore the level of variation in the codon usage of a specific amino acid, glutamine, in relation to the number of consecutive glutamine residues. We show that CAG triplets are consistently more abundant in short glutamine homorepeats (polyQ, four to eight residues) than in shorter glutamine stretches (one to three residues), leading to the evolutionary growth of the repeat region in a CAG-dependent manner. The length of orthologous polyQ regions is mostly stable in primates, particularly the short ones. Interestingly, given a short polyQ the CAG usage is higher in unstable-in-length orthologous polyQ regions. This indicates that CAG triplets produce the necessary instability for a glutamine stretch to grow. Proteins related to polyQ-associated diseases behave in a more extreme way, with longer glutamine stretches in human and evolutionarily closer nonhuman primates, and an overall higher CAG usage. In the light of our results, we suggest an evolutionary model to explain the glutamine codon usage in polyQ regions. | en_GB |
| dc.description.sponsorship | DFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin | - |
| dc.language.iso | eng | - |
| dc.rights | CC BY | de_DE |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
| dc.subject.ddc | 570 Biowissenschaften | de_DE |
| dc.subject.ddc | 570 Life sciences | en_GB |
| dc.title | Glutamine codon usage and polyQ evolution in primates depend on the Q stretch length | en_GB |
| dc.type | Zeitschriftenaufsatz | de_DE |
| dc.identifier.doi | http://doi.org/10.25358/openscience-378 | - |
| jgu.type.dinitype | article | - |
| jgu.type.version | Published version | en_GB |
| jgu.type.resource | Text | - |
| jgu.organisation.department | FB 10 Biologie | - |
| jgu.organisation.number | 7970 | - |
| jgu.organisation.name | Johannes Gutenberg-Universität Mainz | - |
| jgu.rights.accessrights | openAccess | - |
| jgu.journal.title | Genome biology and evolution | - |
| jgu.journal.volume | 10 | - |
| jgu.journal.issue | 3 | - |
| jgu.pages.start | 816 | - |
| jgu.pages.end | 825 | - |
| jgu.publisher.year | 2018 | - |
| jgu.publisher.name | Oxford Univ. Press | - |
| jgu.publisher.place | Oxford | - |
| jgu.publisher.uri | http://dx.doi.org/10.1093/gbe/evy046 | - |
| jgu.publisher.issn | 1759-6653 | - |
| jgu.notes.public | Andrade, Miguel veröffentlicht unter: Andrade-Navarro, Miguel A. | de_DE |
| jgu.organisation.place | Mainz | - |
| jgu.subject.ddccode | 570 | - |
| opus.date.accessioned | 2018-05-18T08:15:26Z | - |
| opus.date.modified | 2018-05-18T08:15:34Z | - |
| opus.date.available | 2018-05-18T10:15:26 | - |
| opus.subject.dfgcode | 00-000 | - |
| opus.organisation.string | FB 10: Biologie: Institut für Organismische und Molekulare Evolutionsbiologie | de_DE |
| opus.identifier.opusid | 58168 | - |
| opus.institute.number | 1011 | - |
| opus.metadataonly | false | - |
| opus.type.contenttype | Keine | de_DE |
| opus.type.contenttype | None | en_GB |
| opus.affiliated | Mier, Pablo | - |
| opus.affiliated | Andrade, Miguel | - |
| jgu.publisher.doi | 10.1093/gbe/evy046 | |
| jgu.organisation.ror | https://ror.org/023b0x485 | |
| Appears in collections: | JGU-Publikationen | |
