Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-291
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dc.contributor.authorFoerster, Friedrich-
dc.contributor.authorHess, Moritz-
dc.contributor.authorGerhold-Ay, Aslihan-
dc.contributor.authorMarquardt, Jens-
dc.contributor.authorBecker, Diana-
dc.contributor.authorGalle, Peter R.-
dc.contributor.authorSchuppan, Detlef-
dc.contributor.authorBinder, Harald-
dc.contributor.authorBockamp, Ernesto-
dc.date.accessioned2018-10-17T13:30:21Z-
dc.date.available2018-10-17T15:30:21Z-
dc.date.issued2018-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/293-
dc.description.abstractThe general relevance of the immune system for cancer development and therapy is increasingly recognized. However and although the immune contexture of most human cancer types has been determined, a global characterisation of the immune tumour microenvironment in hepatocellular carcinoma (HCC) is lacking. Equally, differences in the immune contexture of HCC between different patient subgroups and its effect on survival remain to be established. Here we report an in silico analysis of the immune contexture of human HCC. Using large deep sequencing HCC tumour, adjacent non-tumour and healthy liver high-dimensional data sets, we were able to reveal previously unrecognized differences in the immune contexture of HCC. Strikingly, we found that different etiologies and HCC stages were not associated with major changes in the immune contexture. In contrast, the presence of T cells and cytotoxic cells as well as the absence of macrophages and Th2 cells positively correlated with patient survival. Based on these novel findings, we developed a prognostic score that accurately distinguishes between patients with good and poor survival. Our study provides the first global characterisation of the immune contexture of HCC and will have direct implications for future HCC therapies.en_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin-
dc.language.isoeng-
dc.rightsCC BYde_DE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subject.ddc610 Medizinde_DE
dc.subject.ddc610 Medical sciencesen_GB
dc.titleThe immune contexture of hepatocellular carcinoma predicts clinical outcomeen_GB
dc.typeZeitschriftenaufsatzde_DE
dc.identifier.urnurn:nbn:de:hebis:77-publ-585080-
dc.identifier.doihttp://doi.org/10.25358/openscience-291-
jgu.type.dinitypearticle-
jgu.type.versionPublished versionen_GB
jgu.type.resourceText-
jgu.organisation.departmentFB 04 Medizin-
jgu.organisation.number2700-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titleScientific reports-
jgu.journal.volume8-
jgu.pages.alternativeArt. 85351-
jgu.publisher.year2018-
jgu.publisher.nameMacmillan Publishers Limited, part of Springer Nature-
jgu.publisher.placeLondon-
jgu.publisher.urihttp://dx.doi.org/10.1038/s41598-018-21937-2-
jgu.publisher.issn2045-2322-
jgu.organisation.placeMainz-
jgu.subject.ddccode610-
opus.date.accessioned2018-10-17T13:30:21Z-
opus.date.modified2018-10-25T09:55:44Z-
opus.date.available2018-10-17T15:30:21-
opus.subject.dfgcode00-000-
opus.organisation.stringFB 04: Medizin: Institut für Med. Biometrie, Epidemologie und Informatikde_DE
opus.organisation.stringFB 04: Medizin: I. Medizinische Klinik und Poliklinikde_DE
opus.organisation.stringFB 04: Medizin: Institut für Translationale Immunologie (TIM)de_DE
opus.identifier.opusid58508-
opus.institute.number0424-
opus.institute.number0425-
opus.institute.number0475-
opus.metadataonlyfalse-
opus.type.contenttypeKeinede_DE
opus.type.contenttypeNoneen_GB
opus.affiliatedGerhold-Ay, Aslihan-
opus.affiliatedMarquardt, Jens-
opus.affiliatedGalle, Peter R.-
opus.affiliatedSchuppan, Detlef-
opus.affiliatedBinder, Harald-
jgu.publisher.doi10.1038/s41598-018-21937-2
jgu.organisation.rorhttps://ror.org/023b0x485
Appears in collections:JGU-Publikationen

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