Autoren:	Gonzalez-Escamilla, Gabriel Muthuraman, Muthuraman Chirumamilla, Venkata C. Vogt, Johannes Groppa, Sergiu
Titel:	Brain networks reorganization during maturation and healthy aging-emphases for resilience
Online-Publikationsdatum:	19-Dez-2018
Erscheinungsdatum:	2018
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	Maturation and aging are important life periods that are linked to drastic brain reorganization processes which are essential for mental health. However, the development of generalized theories for delimiting physiological and pathological brain remodeling through life periods linked to healthy states and resilience on one side or mental dysfunction on the other remains a challenge. Furthermore, important processes of preservation and compensation of brain function occur continuously in the cerebral brain networks and drive physiological responses to life events. Here, we review research on brain reorganization processes across the lifespan, demonstrating brain circuits remodeling at the structural and functional level that support mental health and are parallelized by physiological trajectories during maturation and healthy aging. We show evidence that aberrations leading to mental disorders result from the specific alterations of cerebral networks and their pathological dynamics leading to distinct excitability patterns. We discuss how these series of large-scale responses of brain circuits can be viewed as protective or malfunctioning mechanisms for the maintenance of mental health and resilience.
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-259
URN:	urn:nbn:de:hebis:77-publ-587159
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	Frontiers in psychiatry 9
Seitenzahl oder Artikelnummer:	Art. 601
Verlag:	Frontiers Research Foundation
Verlagsort:	Lausanne
Erscheinungsdatum:	2018
ISSN:	1664-0640
URL der Originalveröffentlichung:	http://dx.doi.org/10.3389/fpsyt.2018.00601
DOI der Originalveröffentlichung:	10.3389/fpsyt.2018.00601
Enthalten in den Sammlungen:	JGU-Publikationen