Autoren:	Florin, Luise Lang, Thorsten
Titel:	Tetraspanin assemblies in virus infection
Online-Publikationsdatum:	19-Dez-2018
Erscheinungsdatum:	2018
Sprache des Dokuments:	Englisch
Zusammenfassung/Abstract:	Tetraspanins are a family of four-span transmembrane proteins, known as plasma membrane ‘master organizers’. They form tetraspanin-enriched microdomains (TEMs or TERMs) through lateral association with one another and other membrane proteins. If multiple microdomains associate with each other, larger platforms can form. For infection, viruses interact with multiple cell surface components including receptors, activating proteases, and signaling molecules. It appears that tetraspanins such as CD151, CD82, CD81, CD63, CD9, Tspan9, and Tspan7 coordinate these associations by concentrating the interacting partners into tetraspanin platforms. In addition to mediating viral attachment and entry, these platforms may also be involved in intracellular trafficking of internalized viruses and assist in defining virus assembly and exit sites. In conclusion, tetraspanins play a role in viral infection at different stages of the virus replication cycle. The present review highlights recently published data on this topic, with a focus on events at the plasma membrane. In light of these findings, we propose a model for how tetraspanin interactions may organize cofactors for viral infection into distinct molecular platforms.
DDC-Sachgruppe:	610 Medizin 610 Medical sciences
Veröffentlichende Institution:	Johannes Gutenberg-Universität Mainz
Organisationseinheit:	FB 04 Medizin
Veröffentlichungsort:	Mainz
ROR:	https://ror.org/023b0x485
DOI:	http://doi.org/10.25358/openscience-251
URN:	urn:nbn:de:hebis:77-publ-587071
Version:	Published version
Publikationstyp:	Zeitschriftenaufsatz
Nutzungsrechte:	CC BY
Informationen zu den Nutzungsrechten:	https://creativecommons.org/licenses/by/4.0/
Zeitschrift:	Frontiers in immunology 9
Seitenzahl oder Artikelnummer:	Art. 1140
Verlag:	Frontiers Media
Verlagsort:	Lausanne
Erscheinungsdatum:	2018
ISSN:	1664-3224
URL der Originalveröffentlichung:	http://dx.doi.org/10.3389/fimmu.2018.01140
DOI der Originalveröffentlichung:	10.3389/fimmu.2018.01140
Enthalten in den Sammlungen:	JGU-Publikationen