Please use this identifier to cite or link to this item: http://doi.org/10.25358/openscience-154
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dc.contributor.authorIrsheid, Lina-
dc.contributor.authorWehler, Thomas-
dc.contributor.authorBorek, Christoph-
dc.contributor.authorKiefer, Werner-
dc.contributor.authorBrenk, Ruth-
dc.contributor.authorOrtiz-Soto, Maria Elena-
dc.contributor.authorSeibel, Jürgen-
dc.contributor.authorSchirmeister, Tanja-
dc.date.accessioned2019-06-17T09:39:55Z-
dc.date.available2019-06-17T11:39:55Z-
dc.date.issued2019-
dc.identifier.urihttps://openscience.ub.uni-mainz.de/handle/20.500.12030/156-
dc.description.abstractGolgi α-mannosidase II (GMII) is a glycoside hydrolase playing a crucial role in the N-glycosylation pathway. In various tumour cell lines, the distribution of N-linked sugars on the cell surface is modified and correlates with the progression of tumour metastasis. GMII therefore is a possible molecular target for anticancer agents. Here, we describe the identification of a non-competitive GMII inhibitor using computer-aided drug design methods including identification of a possible allosteric binding site, pharmacophore search and virtual screening.en_GB
dc.description.sponsorshipDFG, Open Access-Publizieren Universität Mainz / Universitätsmedizin-
dc.language.isoeng-
dc.rightsCC BYde_DE
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/-
dc.subject.ddc570 Biowissenschaftende_DE
dc.subject.ddc570 Life sciencesen_GB
dc.titleIdentification of a potential allosteric site of Golgi α-mannosidase II using computer-aided drug designen_GB
dc.typeZeitschriftenaufsatzde_DE
dc.identifier.urnurn:nbn:de:hebis:77-publ-591098-
dc.identifier.doihttp://doi.org/10.25358/openscience-154-
jgu.type.dinitypearticle-
jgu.type.versionPublished versionen_GB
jgu.type.resourceText-
jgu.organisation.departmentFB 04 Medizin-
jgu.organisation.departmentFB 09 Chemie, Pharmazie u. Geowissensch.-
jgu.organisation.number2700-
jgu.organisation.number7950-
jgu.organisation.nameJohannes Gutenberg-Universität Mainz-
jgu.rights.accessrightsopenAccess-
jgu.journal.titlePLOS ONE-
jgu.journal.volume14-
jgu.journal.issue5-
jgu.pages.alternativee0216132-
jgu.publisher.year2019-
jgu.publisher.namePLOS-
jgu.publisher.placeSan Francisco, California, US-
jgu.publisher.urihttp://dx.doi.org/10.1371/journal.pone.0216132-
jgu.publisher.issn1932-6203-
jgu.organisation.placeMainz-
jgu.subject.ddccode570-
opus.date.accessioned2019-06-17T09:39:55Z-
opus.date.modified2019-06-17T09:47:47Z-
opus.date.available2019-06-17T11:39:55-
opus.subject.dfgcode00-000-
opus.organisation.stringFB 09: Chemie, Pharmazie und Geowissenschaften: Institut für Pharmazie und Biochemiede_DE
opus.organisation.stringFB 04: Medizin: III. Medizinische Klinik und Poliklinikde_DE
opus.identifier.opusid59109-
opus.institute.number0910-
opus.institute.number0427-
opus.metadataonlyfalse-
opus.type.contenttypeKeinede_DE
opus.type.contenttypeNoneen_GB
opus.affiliatedIrsheid, Lina-
opus.affiliatedWehler, Thomas-
opus.affiliatedBorek, Christoph-
opus.affiliatedKiefer, Werner-
opus.affiliatedSchirmeister, Tanja-
jgu.publisher.doi10.1371/journal.pone.0216132
jgu.organisation.rorhttps://ror.org/023b0x485
Appears in collections:JGU-Publikationen

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