Browsing by Author Efferth, Thomas

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the_cardiac_glycoside_zinc253-20230815154227037.pdf.jpg202324-Aug-2023The cardiac glycoside ZINC253504760 induces parthanatos-type cell death and G2/M arrest via downregulation of MEK1/2 phosphorylation in leukemia cellsZhou, Min; Boulos, Joelle C.; Klauck, Sabine M.; Efferth, Thomas
özenver_nadire-chemometric_an-20210209112718237.pdf.jpg20209-Feb-2021Chemometric and transcriptomic profiling, microtubule disruption and cell death induction by secalonic acid in tumor cellsÖzenver, Nadire; Dawood, Mona; Fleischer, Edmond; Klinger, Anette; Efferth, Thomas
dawood_mona-collateral_sen-20200928110332836.pdf.jpg201913-Jun-2019Collateral sensitivity of parthenolide via NF-κB and HIF-α inhibition and epigenetic changes in drug-resistant cancer cell linesDawood, Mona; Ooko, Edna; Efferth, Thomas
cynaropicrin_disrupts_tubulin-20230815123736975.pdf.jpg202324-Aug-2023Cynaropicrin disrupts tubulin and c-Myc-related signaling and induces parthanatos-type cell death in multiple myelomaBoulos, Joelle C.; Omer, Ejlal A.; Rigano, Daniela; Formisano, Carmen; Chatterjee, Manik; Leich, Ellen; Klauck, Sabine M.; Shan, Le-tian; Efferth, Thomas
cytotoxicity_and_modes_of_act-20221006095214615.pdf.jpg20136-Oct-2022Cytotoxicity and modes of action of the methanol extracts of six Cameroonian medicinal plants against multidrug-resistant tumor cellsKuete, Victor; Fankam, Aimé G.; Wiench, Benjamin; Efferth, Thomas
cytotoxicity_of_endoperoxides-20220925182710959.pdf.jpg201721-Oct-2022Cytotoxicity of endoperoxides from the Caribbean sponge Plakortis halichondrioides towards sensitive and multidrug-resistant leukemia cells : acids vs. esters activity evaluationSchirmeister, Tanja; Oli, Swarna; Wu, Hongmei; Della Sala, Gerardo; Costantino, Valeria; Seo, Ean-Jeong; Efferth, Thomas
cytotoxicity_of_the_sesquiter-20220925164201931.pdf.jpg201517-Oct-2022Cytotoxicity of the sesquiterpene lactones neoambrosin and damsin from ambrosia maritima against multidrug-resistant cancer cellsSaaed, Mohamed; Jacob, Stefan; Sandjo, Louis P.; Sugimoto, Yoshikazu; Khalid, Hassan E.; Opatz, Till; Thines, Eckhard; Efferth, Thomas
saeed_mohamed_e._m.-drug_repurposi-20210510114527807.pdf.jpg202110-May-2021Drug repurposing using transcriptome sequencing and virtual drug screening in a patient with glioblastomaSaeed, Mohamed E. M.; Kadioglu, Onat; Greten, Henry Johannes; Yildirim, Adem; Mayr, Katharina; Wenz, Frederik; Giordano, Frank; Efferth, Thomas
kadioglu_onat-identification-20210209101413928.pdf.jpg20209-Feb-2021Identification of novel rare ABCC1 transporter mutations in tumor biopsies of cancer patientsKadioglu, Onat; Saeed, Mohamed; Munder, Markus; Spuller, Andreas; Greten, Henry Johannes; Efferth, Thomas
identification_of_potential_n-20220701123610800.pdf.jpg20214-Jul-2022Identification of potential novel drug resistance mechanisms by genomic and transcriptomic profiling of colon cancer cells with p53 deletionKadioglu, Onat; Saeed, Mohamed; Mahmoud, Nuha; Azawi, Shaymaa; Mrasek, Kristin; Liehr, Thomas; Efferth, Thomas
the_immunosuppressive_activit-20221017113132463.pdf.jpg20219-Nov-2022The immunosuppressive activity of artemisinin-type drugs towards inflammatory and autoimmune diseasesEfferth, Thomas; Oesch, Franz
interaction_of_antihistaminic-20220924203829700.pdf.jpg20167-Oct-2022Interaction of antihistaminic drugs with human translationally controlled tumor protein (TCTP) as novel approach for differentiation therapySeo, Ean-Jeong; Efferth, Thomas
network_pharmacology_of_tript-20220729131545075.pdf.jpg20213-Aug-2022Network pharmacology of triptolide in cancer cells : implications for transcription factor bindingSeo, Ean-Jeong; Dawood, Mona; Hult, Annika K.; Olsson, Martin L.; Efferth, Thomas
a_novel_ligand_of_the_transla-20220701124103992.pdf.jpg20214-Jul-2022A novel ligand of the translationally controlled tumor protein (TCTP) identified by virtual drug screening for cancer differentiation therapyFischer, Nicolas; Seo, Ean-Jeong; Abdelfatah, Sara; Fleischer, Edmond; Klinger, Anette; Efferth, Thomas
prediction_of_cancer_drug_res-20220913190849926.pdf.jpg201514-Sep-2022Prediction of cancer drug resistance and implications for personalized medicineVolm, Manfred; Efferth, Thomas
pyrrolizidine_alkaloids_cause-20220701131337232.pdf.jpg20224-Jul-2022Pyrrolizidine alkaloids cause cell cycle and DNA damage repair defects as analyzed by transcriptomics in cytochrome P450 3A4-overexpressing HepG2 clone 9 cellsAbdelfatah, Sara; Naß, Janine; Knorz, Caroline; Klauck, Sabine M.; Küpper, Jan-Heiner; Efferth, Thomas
selection_of_safe_artemisinin-20220624130755185.pdf.jpg202127-Jun-2022Selection of safe artemisinin derivatives using a machine learning-based cardiotoxicity platform and in vitro and in vivo validationKadioglu, Onat; Klauck, Sabine M.; Fleischer, Edmond; Shan, Letian; Efferth, Thomas
3261.pdf.jpg201231-Jan-2013Shikonin directly targets mitochondria and causes mitochondrial dysfunction in cancer cellsWiench, Benjamin; Eichhorn, Tolga; Paulsen, Malte; Efferth, Thomas
shikonin_inhibits_cell_growth-20220517120048851.pdf.jpg202220-Dec-2022Shikonin inhibits cell growth of sunitinib-resistant renal cell carcinoma by activating the necrosome complex and inhibiting the AKT/mTOR signaling pathwayMarkowitsch, Sascha D.; Vakhrusheva, Olesya; Schupp, Patricia; Akele, Yasminn; Kitanovic, Jovana; Slade, Kimberly S.; Efferth, Thomas; Thomas, Anita; Tsaur, Igor; Mager, René; Haferkamp, Axel; Jüngel, Eva
markowitsch_sascha_d.-shikonin_reduc-20210514144150228.pdf.jpg202131-May-2021Shikonin reduces growth of docetaxel-resistant prostate cancer cells mainly through necroptosisMarkowitsch, Sascha D.; Juetter, Kira M.; Schupp, Patricia; Hauschulte, Kristine; Vakhrusheva, Olesya; Slade, Kimberly Sue; Thomas, Anita; Tsaur, Igor; Cinatl, Jindrich; Michaelis, Martin; Efferth, Thomas; Haferkamp, Axel; Juengel, Eva